New test could be breast cancer breakthrough

Aug 20, 2009 | Posted by: roboblogger | Full story: KTVX

There are 190,000 women with breast cancer in the US. 40,000 of them will die. Now Utah doctors are using a new test that increases survival and prevents women from unnecessary chemotherapy.

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Gail Perry

United States

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#1
Aug 20, 2009
 
This is frustrating for those of us who have had breast cancer. There was very specific information for colorectal cancer and prostate cancer but only vague generalities for breast cancer.

Did they find no statistically significant trends for breast cancer? They apparently found an age break -- but didn't tell us what it was.

One more thing to ask my oncologist, but a more complete report would have been so welcome.

Since: Dec 05

Clark, NJ

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#2
Aug 20, 2009
 
The genetic analysis of Oncotype DX predicts which women will have a greater chance of breast cancer recurrence. The test looks at 21 genes that influence the behavior of breast cancer cells. Until this test, it had been difficult to pinpoint which women would benefit most from chemotherapy, and those which wouldn't.

MammaPrint is another genetic test that could help patients with early-stage breast cancer predict their chance of relapse, information that could save many patients from unnecessary chemotherapy. This test looks at the expression of 70 genes linked to breast cancer with an accuracy level of 96.7% as determined by a study published in the New England Journal of Medicine. It is now available in the US by Agendia.

Another molecular-targeted breast prognostic test called Mammostrat. It is validated with the usual, retrospective, non-randomized study using archival tissues and uniform batch processing and slide interpretation. It utilizes five immunohistochemical (IHC) biomarkers to classify patients into high, moderate, or low-risk categories for disease recurrence.

These new gene expression profiling tests enable the oncologist and breast cancer surgeon to more accurately determine who should be treated and who should not be treated with chemotherapy, but they cannot predict chemo response.

These laboratory tests are a tool for the oncologist. The oncologist should take advantage of all the tools available to him/her to treat a patient. And since studies show that only 25-30% of patients do respond to chemotherapy that is available to them (and even less for "targeted" drugs), there should be due consideration to looking at the advantage of molecular and cellular assay tests to the resistance that has been found to chemotherapy drugs.

These tests can enhance the ability to distinguish between "low" risk and "high" risk patients. Patients in the high-risk group, who would benefit from chemotherapy can then be pre-tested to see what treatments have the best opportunity of being successful, and offers a better chance of tumor response resulting in progression-free and overall survival, while those in the lower-risk groups can be spared the unnecessary toxicity, particularly associated with ineffective treatment.
Gail Perry

United States

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#3
Aug 20, 2009
 
GDP thanks so much for telling us that these tests are tools. Who knew? Yes, you got it. The point is better targeted therapy. Bravo.

Care to tell us what your expertise is?
shirley

Tours, France

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#4
Aug 23, 2009
 
gdpawel -dont bother replying to this mad women. She stalks people and HAS to have the last word. I think she is a drunk to be honest.
Gail Perry

United States

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#5
Aug 23, 2009
 
You just can't bear for anyone to disagree with you, Shirley, and now you do appear to be stalking me, following me from discussion to discussion.

By the way I don't drink and would recommend that you do not, as it can encourage the development of blood vessels in tumors should you have the misfortune for your breast cancer to return.

I would also suggest you drop the personal attacks. It does not add to your credibility.

Since: Dec 05

Clark, NJ

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#6
Aug 23, 2009
 
I know Shirley.
Cody

UK

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#9
Sep 23, 2013
 
I have ordered 2 times from this website PILLSMEDSHOP. COM . I called yesterday the customer care and asked for a discount as i was about to order twice the regular amount.

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