Cancer trials show one year on Roche's Herceptin is best
Extending treatment with Roche's breast cancer drug Herceptin to two years from the one year current standard is not worth while, trial data showed on Monday, but shortening treatment to six months also looks unlikely to benefit patients.
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Since: Dec 05
#1 Oct 1, 2012
Herceptin Studies Offer A Mixed Bag
Aside from the issue of congestive heart failure, past studies have suggested a potentially very serious weakness with Herceptin, the problem with central nervous system (CNS) metastasis.
A study from the same Dana Farber Cancer Institute identified CNS metastases in 34% of the women who received Herceptin-based therapy for metastatic breast carcinoma. CNS disease is defined as one or more brain metastases or leptomeningeal carcinomatous (carcinomatous memingitis).
Ironically, that is the same problem they are having with the T-DM1 trial. Brain mets! Some think that patients on the T-DM1 (trastuzumab emtansine) trial should also be given some straight Herceptin, which they think will cross the blood-brain barrier (BBB) and give a certain amount of protection.
The only way for that to happen is a patient may also have to be subjected to an “intrathecal” injection of T-DM1. Herceptin does not cross the BBB because it is a “large” molecule drug. One thing you can definitely say is the T-DM1 is an investigational agent, or just plain experimental.
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