Breast cancer drug Arimidex cleared for use in post menopausal ...

Full story: Earth Times 135
AstraZeneca's breast cancer drug Arimidex has been cleared by the European medicine regulators, for use as a new treatment option, in women suffering from post menopausal early breast cancer, who are currently ... Full Story
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Sharon

Palm Desert, CA

#1 Jul 24, 2006
I have taken Arimidex twice. The first time for 2 months and got very painful joints and leg cramps and hot flashes. Then I stopped for 2 months and the doctorencouraged me to try again. So I did and now it is one month later and I have the same side effects again and mood changes.
Alyce Tipton

Cambridge, MA

#2 Jul 24, 2006
I have taken arimidex for almost 1 year now. The side effects for me are pain in the feet and joint pains. Hot flashes and mood changes. I guess every medicine comes with some side effects but I'm willing to go the extra mile and work out and walk and stay active .So things are not so great right now but I believe that I'll be around a long time to help other people through their journey from my experiences.
DENISE

Lapeer, MI

#3 Jul 25, 2006
Sharon wrote:
I have taken Arimidex twice. The first time for 2 months and got very painful joints and leg cramps and hot flashes. Then I stopped for 2 months and the doctorencouraged me to try again. So I did and now it is one month later and I have the same side effects again and mood changes.
I took Arimidex less than 3 months...I had severe foot, some hand pain, especially the one I use most and some neck pain, it was getting worse every week, now they think I may have drug induced Neuropathy- which is very rare to of happened. I was recommended Tamoxifen first, then I was put in Menopause at age 43 from Chemotherapy so they gave me Arimidex after radiation. Tamoxifen i have less hot flashes. Neurotin is being given for foot, hand pain and stopped most all hot flashes too!
Connie

United States

#4 Jul 27, 2006
Hi Sharon,
I too, took Arimidex twice.
I suffered from numbness and pain in my feet and pins and needles in my legs, numbness in my fingertips. Also, terrible pain in my legs at night. The initial pain started after only 2 weeks on the Arimidex.
I was only off it for 14 days, both times before I went back on it. That was my onc's. suggestion. I realize that wasn't long enough.
Switched to Femara. Same numbness and other side effects as with Arimidex. Not horrible leg pains.
I am doing research for Breast Cancer Action as to whether other countries list the same side effects for the three AI's.
Would love to hear about your complete side effects.
You may want to check into the site which is www.bcaction.org
If you wish to contact me please feel free to do so.
Ruby741us@yahoo.com
Becky Stockwell

Reno, NV

#5 Sep 17, 2006
I wrote recently, and was feeing good but yesterday 9/16,I got another urinary tract infection. One in June 3 days after beginning this drug. It think I will stop. I had never had a urinary tract infection EVER, before arimedix, so I think it is time to stop.
Becky Very uncomfortable with blood in urine and fever.
JCB

Minot, ND

#6 Dec 18, 2006
After finishing my chemotherapy for breast cancer I have been on Femara for 7 months. Have developed hand pain, especially the thumbs.Seems like it appeared out of nowhere. No previous hand discomfort except some tingling and numbness during chemotherapy with cytoxin.
Lynn

Raleigh, NC

#7 Dec 19, 2006
JCB wrote:
After finishing my chemotherapy for breast cancer I have been on Femara for 7 months. Have developed hand pain, especially the thumbs.Seems like it appeared out of nowhere. No previous hand discomfort except some tingling and numbness during chemotherapy with cytoxin.
My thumb joint pain became so intense that a hand surgeon had me planned for 2 joint replacements!! Since stopping Arimidex, my joint pain is just a bad memory! Lynn
i speak the truth

United States

#8 Dec 20, 2006
anybody here know anyone with leiomyosarcoma???
DENISE

Monroe, MI

#9 Dec 26, 2006
What is Leiomyosarcoma?
I wrote about the arimidex because I'm still upset that since arimidex, I've had other side effects too. Started with the Neuropathy symptom...feet, hand, pain, numbness, tingling, burning foot pad area. Thumb on right hand was severe arthritic type pain, index finger next to it hurted too but not as much. Had neck pain too, leading down the shoulders, some subsided. Now think my immune system is very weak based on diagnoses of autoimmune disorder, still in the works of figuring out. Had a Tetanus shot, found out theres another tetanus available for low immunity and SEVERE spasms in left upper & SOME LOWER arm resulted from the Shot, CAUSING HERNIATED DISC! My neck is worse and now they think I have connective tissue disease POSSIBLY even MS. Will find out soon. This was a result of Chemotherapy weakening the immune system. What a nightmare...Fatigue, joint, hand, feet, now leg pain, PREDOMINATELY LEFT SIDE. Arthritus type symptoms(they say??) is starting in several places, especially neck. sUSPECTED POSSIBLE STROKE. All happened after arimidex. Before taking arimidex, I began working again, felt real good, then it all started within a month.
DENISE

Monroe, MI

#10 Dec 26, 2006
Has anyone heard of all the side effects concerning chemo brain? They claim it goes away. I dont think so. The chemo brain supposedly takes place in the "Basal Ganglia" area of the brain. according to the news paper article I read early fall. Ironically someone I know having chemo brain started having strokes after starting the chemo pill...maybe ironic with the pill, but the stroke was in the same place of her brain - odd don't ya think? This causes me to think that maybe the basal ganglia area of the brain which has alot to do with motor skills, legs, co-ordination, fatigue, memory if you read up on that type of stroke you'll see. The chemo brain thing is similar to me. fatigue, memory, weakness, leg pain and more. Any thoughts here?
LINDA

Lolo, MT

#11 Dec 31, 2006
I've been taking Arimidex for almost three years. About 6 months ago I started getting severe (and I mean severe!) leg cramps at night (which seem to have replaced foot pain-that's gone all of a sudden). My oncologist prescribed Baclofen but I don't want to take it after reading about it in the PDR (it's prescribed for cerebral palsy--yikes!). Has anyone found a solution to the problem that doesn't involve drugs that may be worse than the problem? I don't want to stop the Arimidex before my 5 years are up. Any ideas?
Lynn

Raleigh, NC

#12 Jan 1, 2007
LINDA wrote:
I've been taking Arimidex for almost three years. About 6 months ago I started getting severe (and I mean severe!) leg cramps at night (which seem to have replaced foot pain-that's gone all of a sudden). My oncologist prescribed Baclofen but I don't want to take it after reading about it in the PDR (it's prescribed for cerebral palsy--yikes!). Has anyone found a solution to the problem that doesn't involve drugs that may be worse than the problem? I don't want to stop the Arimidex before my 5 years are up. Any ideas?
Linda, I would see a vein specialist if I were you. I went to a vein clinic and had major vein "renovations" and my leg cramping, etc. is gone. It can also be a vitamin or potassium
deficency. Ask your GP about that one or go on line. My oncologist put me on Vioxx when all my joints started to scream--feet, thumbs, elbows, knees. Yes, it helped; but it was just masking a problem which I still believe was caused by Tamoxifen and then, Arimidex.(Pains stopped after stopping Arimidex almost 3 mos. ago) I agree with you! Get to the root of the problem without adding what could be a potentially dangerous drug to your daily regimen. I cannot for the life of me understand why there is no warning on the label of Arimidex that it can cause severe joint pain..........of course, it hasn't been that long ago that cigarette pkgs. failed to warn smokers that they were killing themselves either! I hope you keep us all posted with your news.(Happy New Year!)
LINDA

Lolo, MT

#13 Jan 1, 2007
Lynn wrote:
<quoted text>
Linda, I would see a vein specialist if I were you. I went to a vein clinic and had major vein "renovations" and my leg cramping, etc. is gone. It can also be a vitamin or potassium
deficency. Ask your GP about that one or go on line. My oncologist put me on Vioxx when all my joints started to scream--feet, thumbs, elbows, knees. Yes, it helped; but it was just masking a problem which I still believe was caused by Tamoxifen and then, Arimidex.(Pains stopped after stopping Arimidex almost 3 mos. ago) I agree with you! Get to the root of the problem without adding what could be a potentially dangerous drug to your daily regimen. I cannot for the life of me understand why there is no warning on the label of Arimidex that it can cause severe joint pain..........of course, it hasn't been that long ago that cigarette pkgs. failed to warn smokers that they were killing themselves either! I hope you keep us all posted with your news.(Happy New Year!)
Thanks for your comments, Lynn. I'll write if I come up with a solution to the leg cramp problem. I find it amusing when I tell someone about it and they say, "I get charlie horses all the time--I just get up and walk around and it goes away." Well, I don't think I could "walk around" with the cramps if my house were on fire! Oh well, beats having breast cancer.
Joanne

Fresno, CA

#14 Jan 4, 2007
Have any of you read the report on symptoms published by Breast Cancer Action? It can be found at http://www.bcaction.org/Pages/GetInformed/AIR...

The part about the high incidence of strokes really has me worried.
Lynn

Raleigh, NC

#15 Jan 4, 2007
Interesting, to say the least! My oncologist mentioned that Arimidex could raise my cholesterol levels (after I mentioned that my Dr. was worried about them) and cause heart problems or stroke. Until that moment the issue had never been raised. The more I read of all these side effects, the more questions I have. I had written in an earlier email that since stopping Arimidex my joint pain was "a thing of the past". What I do have to say is that as soon as wet cold weather hits, my joints hurt enough that I take Advil to releive the pain; the same bad pain I had constantly when I was on the drug. I think my joint deterioration is due to the years I was on Tamoxifen/Arimidex. It probably won't be proven in my lifetime but this "wonder" drug has me wondering. I hope everyone with health issues go to the web site you reccomend........Thanks for the info! Lynn
Ann

United States

#16 Jan 20, 2007
I have been taking Arimidex for about two years. Soon after starting with Arimidex, I began having severe leg cramps (Charlie Horses) at night. I have the cramps even in my thigh. I took quinine sulfate at night, and it helped a lot. It has been removed from the market, and my leg cramps are happening every night when I go to bed.
LINDA wrote:
I've been taking Arimidex for almost three years. About 6 months ago I started getting severe (and I mean severe!) leg cramps at night (which seem to have replaced foot pain-that's gone all of a sudden). My oncologist prescribed Baclofen but I don't want to take it after reading about it in the PDR (it's prescribed for cerebral palsy--yikes!). Has anyone found a solution to the problem that doesn't involve drugs that may be worse than the problem? I don't want to stop the Arimidex before my 5 years are up. Any ideas?
Helen

AOL

#17 Jan 22, 2007
DENISE wrote:
<quoted text>
I took Arimidex less than 3 months...I had severe foot, some hand pain, especially the one I use most and some neck pain, it was getting worse every week, now they think I may have drug induced Neuropathy- which is very rare to of happened. I was recommended Tamoxifen first, then I was put in Menopause at age 43 from Chemotherapy so they gave me Arimidex after radiation. Tamoxifen i have less hot flashes. Neurotin is being given for foot, hand pain and stopped most all hot flashes too!
My husband took neuROTEN it made him have bad night mares and I could not leave him alone.I called it stupid pills.Neck injury from car wreck, he went to chiropractor and is off it.crazy I know but he was not right.the drug messed with his mind after2 weeks enough was enough.
Samara

UK

#18 Feb 6, 2007
Hi...
My Mum has been taking Arimidex for about 8 months now and she has developed Kidney problems out of the blue..raised creatinine levels and potassium...and high blood pressure.
I wonder if anyone else has had similar problems.
Very worried :(
bette

Canada

#19 Feb 13, 2007
I am wondering if anyone developed osteoarthritus after taking tamoxifen? I went through a course of chemo for breast cancer and went on Tamoxifen for 5 years. I am now taking Femara. I have had 2 total knee replacements in the past 2 years. I can't find a link between the treatments and arthritus,but wondered if there were some others who have experienced the same thing.
Julie

Plymouth, UK

#20 Feb 19, 2007
I had twelve months of treatment for breast cancer
chemo and radiotherapy,in 2003. No further treatment as it was not hormone receptive. Whilst having chemotherapy I got what seemmed to be bone pain in the long bones this always eased towards the end of chemo cycles. Since finishing treatment I have started to get very bad pain in most of my joints I have been taking Nsaids which help but pains are getting worse. I am sure that chemo has caused this problem.

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