Paxil and Marijuana

[Brent]

I've just started Paxil and was curious if anyone's experienced significant side effects with the use of marijuana?

I use it pretty regularly to help with anxiety and it really calms me down.

Anyone with experience please speak up!:)

[MAh]

Yeah I find it harder to get high off marijuana now that I am on paxil. The highs are a lot shorter

[Shorty]

I just started taking Paxil for panic attacks and I have been smoking weed for years. I noticed that I actually get a little more high than normal but it doesn't last as long. The other night I smoked (possibly too much) and it triggered a panic attack. I wasn't even thinking about anything in particular that would trigger this reaction. I usually need to be pretty stressed out with a lot on my mind to have an attack. I think the weed may have caused this one. That was the only down side about mixing the two, and it only happened once like I said. I would imagine that in this case, less is more. Hope I helped.

[BrainStinker]

The new pot is so strong that i think that all of its undesirables are amplified too....Think about the receptor traffic jam one could have mixing paxil and high grade pot. If you are injured metally....hmmmm....lets see.....ok, yea don't do it more!!! Come on, the whole idea is not to hurt ourselfs. And the panic attacks are from the come down....I don't hate pot, i just think that it needs to be seriuosly readressed, as whatever it is in the 21st century.

[Danger]

Combining 40 mg. of Paxil and marijuana every day caused psychosis requiring hospitalization in me

[sidious777]

Be careful... I took paxil for 11 years while smoking weed everyday. The pot worsened the depression I already had. I was also prescribed clonazepam and wellbutrin( I took those drugs every day, also). By 2007 I ended up in my local hospital's psych wing. Also I could not urinate. I had to use a catheter for 2 weeks. It was not a pleasant experience.

[Freaked out]

I have been on paxil for awhile now as well as a mood stabilizer. Both times I smoked chronic while on these perscriptions it caused serious panic, anxiety, and a overall sense of worry that I was going to lose it. For me I believe it was the combination of the two that caused these reactions and have decided for me it is not a good idea to smoke weed while on these perscriptions. Let's just say that when these reactions happened it scared the crap out of me.

[NvyBluWS6]

Strange responses considering weed and Paxil effect different enzymes in the brain. The cannanboid receptors in the brain are not SSRI-mediated and not serotonin-mediated. Marijuana can, however, affect norepinephrine and dopamine, two other neurotransmitters that influence mood. Not all SSRIs are affected equally by marijuana. Paxil and Prozac, for example, have greater inhibitory effects on an enzyme in the liver's P450 system, which metabolizes many drugs. Taking SSRIs could prolong the excretion of marijuana from the body. Taking prescription antidepressants and simultaneously self-medicating with marijuana is not a good idea. And not telling the physician who prescribes your antidepressants that you use marijuana is simply a poor and potentially dangerous decision.

[AJF]

you were probably having heart palpitations.....not anxiety attacks from the weed. it happens to me. weed and energy drinks and stuff that messes with your heart rate cause heart palpitations that seem like anxiety attacks. i have them when i would smoke, so i quit, cus they are shitty and not worth it. now im being prescribed paxil and after reading above i dont think i will be smoking anymore.

[Alice]

I just started on paroxetine, which is a generic version of Paxil. I haven't tried weed while on this drug yet, but I tried a legal synthetic weed called pep pourri/spice/k2. This drug, mixed with the paroxetine, gave me a trip... A bad trip... A seven-hour bad trip. It also gave me serious heart palpations which stopped my breathing. So ever since that awful experience, I'm too scared to start again with weed or anything. I wouldn't recommend it.