I just started Diovan today. I'm hopeful after having read the post here on this site. I had been on Inderal LA for over 18 months and gained 63 pounds. I brought the weight gain to my doctor's attention on several occasions, but he never did anything about it. Finally, after having moved, changed doctors, having the Inderal increased to 160 mg/day and the final 20 pounds.... My new doctor decided to change my medication. Inderal simply was not cutting it, causing me to gain weight continually, and took every ounce of energy I had. Going to the bathroom was exhausting to me. I'm SO happy they've finally changed my medications and SO hope that the Diovan HCT will have the weight loss effect on me as well. As I stated, I took my first pill today after arriving at the doctor with a blood pressure of 157/105 and heart rate of 115 today! Goodbye Inderal!!!!!