Avastin increases fatal side effects ...

Avastin increases fatal side effects in cancer patients, study shows

There are 3 comments on the USA Today story from Feb 1, 2011, titled Avastin increases fatal side effects in cancer patients, study shows. In it, USA Today reports that:

Avastin, a drug used in the treatment of multiple cancers. According to a new study cancer patients who combine Avastin and chemo are 50% more likely to die from their treatment -- rather than their disease.

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Since: Dec 05

Reading, PA

#1 Feb 1, 2011
Genentech researchers are looking for tests to help predict how patients will respond to Avastin?

Angiogenesis (growth of blood vessels that feed a tumor) is dependent on VEGF (Vascular Endothelial Growth Factor), a chemical signal produced by cells that stimulates the growth of new blood vessels.

Avastin has been known to be driven by the VEGF pathway. Avastin directly binds to VEGF to directly inhibit angiogenesis. Avastin blocks VEGF and causes existing microcapillaries to die. This is what is measured with an AngioRx Assay (which simultaneously measures direct anti-tumor activity and anti-vascular activity), death of existing endothelial (and associated) cells.

One aspect of this functional profiling assay is that microvascular viability can measure dead microvascular cells in tissue, fluid and peripheral blood specimens to identify potential responders to anti-angiogenic drugs and to assess direct and potentiating anti-angiogenic effects.
Gail Perry

United States

#2 Feb 2, 2011
Still around?

Tell us again what your expertise is, please?

The promise of Avastin has not lived up to the reality of Avastin, unfortunately. And, unfortunately, the test you keep promoting tells what happens in a lab, not in a person's body where there are literally billions of variables acting on the tumor, the person's body and the drug being used.

Even where Avastin has been helpful, for instance in brain cancer, life was only extended by 2 months.

When there's a small benefit, the risks have to be looked at carefully. The problem with Avastin is that the small gain may not be worth the serious side effects.

No lab test can tell how one person will react to any given drug. It can provide SOME potential information about that -- but no guarantees.

GDP has been doggedly promoting this test for years and I would like to know why. It's no magic bullet.
Gail Perry

Saint Petersburg, FL

#3 Feb 8, 2011
GDP, it's six days later. Why won't you tell us what your expertise is? You certainly sound like an expert in your posts.

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