Test to predict breast cancer relapse is approved in U.S.
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Since: Dec 05
#1 Feb 25, 2007
Another new test, that looks at the expression of 70 genes linked to breast cancer, can accurately assess a patient's risk of recurrence or death. The correlations of this are vastly superior to those obtained with standard prognostic markers.
The 70 genes in a woman's tumor analyzed by MammaPrint predict the 10-year survival of the patient at a significance level over three times greater than existing methods and with an accuracy level of 96.7% as determined by a study published in the New England Journal of Medicine.
Existing methods can't distinguish the patients with a high risk for recurrence from those with low risk with comparable accuracy. This new gene expression profiling test enables the oncologist and breast surgeon to more accurately determine who should be treated.
This test, and three other multi-gene tests have been shown to be superior over conventional assessment of risk of future metastatic disease, such as histological assessment of tumor aggressiveness (by grade). One gets more accurate information when using intact RNA isolated from "fresh" tissue than from using degraded RNA, which is present in paraffin-fixed tissues.
These tests have enormous implications for the short-term future of cancer research in general, and is one of the truly great cancer breakthroughs of our time. This DNA microarray will prove to be highly complementary to the parellel breakthrough efforts in targeted therapy through cell culture assays like the EGFRx™ Assay.
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