Analysis: Antidepressants do little f...

Analysis: Antidepressants do little for patients with mild or m...

There are 39 comments on the Columbus Dispatch story from Jan 5, 2010, titled Analysis: Antidepressants do little for patients with mild or m.... In it, Columbus Dispatch reports that:

Antidepressants do little more than sugar pills for patients with mild or moderate depression, according to a new analysis of six studies that included 718 people.

Join the discussion below, or Read more at Columbus Dispatch.

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Bo Dark

Powell, OH

#23 Jan 5, 2010
Laura wrote:
I always felt that people should ask themselves what is the root of their depression.Deal with what's causing it and depression will be gone!
Laura, I agree with your statement except that the last five words )"...and depression will be gone.") makes the curative process seem finger-snapping easy.
It can be a long heart-wrenching process to discover why a person is depressed and what to do about it.
Being sold more useless drugs is certainly not the way to go.
Bo Dark

Powell, OH

#24 Jan 5, 2010
JMO wrote:
I am Bi-Polar and without my medication, which includes a mode stabilizer and two antidipressants, I would be hell to live with. I was diagnosed in June of 1988 and have still had some ups and downs every once in awhile. But the benefits I get for my Manic-Depressive illness is the best route to take. I have done counseling for years and it doesn't help my moods any. Medications for me is the best way to go.
Wow, JMO, have you done counseling for years with the same counselor? Many counselors
(psychiatrists) believe themselves that medication is the only solution.
And don't misunderstand me: if it is, it is. But it is too easy for them to believe in drugs and maybe not to be willing to talk about the hurtin' aspects of your life. Many psychiatrists have two important communications:
"Well, our time is up."
"Do you need a prescription renewal?"
Good luck JMO.
BethOhio

Columbus, OH

#26 Jan 6, 2010
Laura wrote:
I always felt that people should ask themselves what is the root of their depression.Deal with what's causing it and depression will be gone!
Unfortunately, it's not always that easy. Depression can be caused by so many things. Chemical imbalance in the brain, phsyical exhuastion, emotional trauma, etc. I briefly took Prozac after my god-daughter was killed by a drunk driver, and that, combined with counseling, helped considerably. But it's not always an issue of just "deal with what's causing it". Depression can alter your body chemistry and cause a legitimate imbalance. In many cases, medication is the only way to regulate it.
Laura

Reynoldsburg, OH

#27 Jan 6, 2010
Bo Dark wrote:
<quoted text>
Laura, I agree with your statement except that the last five words )"...and depression will be gone.") makes the curative process seem finger-snapping easy.
It can be a long heart-wrenching process to discover why a person is depressed and what to do about it.
Being sold more useless drugs is certainly not the way to go.
I agree that it is not that easy,but usually what results from the "pill" answer,is years of drug dependency and never getting to the root causation of the issue.
Columbus Reader

Columbus, OH

#28 Jan 6, 2010
Laura wrote:
I always felt that people should ask themselves what is the root of their depression.Deal with what's causing it and depression will be gone!
You are clueless. It is often a chemical imbalance. Life situations can make it worse. Therapy can help, but it is not the only way to battle depression.

SSRIs (selective serotonin re-uptake inhibitors-anti depressants) relieve symptoms of depression by blocking the reabsorption (reuptake) of serotonin by certain nerve cells in the brain. This leaves more serotonin available in the brain. Increased serotonin enhances neurotransmission — the sending of nerve impulses — and improves mood. In addition, exercise can also be a great help by increasing endorphines into the brain. But it is often difficult for people who are depressed to even imagine getting off the couch let alone begin an exercise regime. Once the anti-depressant begins to work and the depression lessens, exercise becomes something do-able to these folks. Once free from depression they can also better "deal" with the issues in their life.
Ohio Lawyer

Columbus, OH

#29 Jan 6, 2010
Linda wrote:
That way if your so depressed you can't work, they will not acknowledge this and you won't get paid. It's all about the money$$$$$$
Wrong again, Linda. It is actually very difficult to be declared too disabled to work based on depression alone. Be a little less dumb and cynical and take the study at face value.
Ohio Lawyer

Columbus, OH

#30 Jan 6, 2010
MSW wrote:
Too bad this study looked at two medications that aren't widely used by patients. Fluoxetine (Prozac) has shown really strong effectiveness in academic studies, especially with teenage depression, and similar studies have documented the effectiveness of other medications such as Zoloft and Paxil.
If only newspapers wouldn't jump to conclusions...
The newspaper accurately reported the findings of a large study.
Ohio Lawyer

Columbus, OH

#31 Jan 6, 2010
rebel wrote:
<quoted text>
sooo many people do this: claim they are depressed, then they get money from taxpayers. It is unbelievable.
Damn near nobody "claims they are depressed and gets money from taxpayers." You don't know a damn thing you lying ignorant schmuck.
skeptical observer

Columbus, OH

#32 Jan 6, 2010
MSW wrote:
Too bad this study looked at two medications that aren't widely used by patients. Fluoxetine (Prozac) has shown really strong effectiveness in academic studies, especially with teenage depression, and similar studies have documented the effectiveness of other medications such as Zoloft and Paxil.
If only newspapers wouldn't jump to conclusions...
The article refers to results from six studies. I can't imagine those studies did not include the widely prescribed drugs that you mention, nor can I imagine that the reporter would not have said so. If you have citations proving otherwise, please provide them.
Rebutting MSW

Columbus, OH

#33 Jan 6, 2010
From today's NY Times article:

"Three of the trials were of Paxil, from GlaxoSmithKline, a so-called S.S.R.I., and the other three were of imipramine, an older generic drug from the class known as tricyclics..... Patients with scores of less than 25 got little or no added benefit from the medications.

“We were able to give an overall estimate of effectiveness for the first time in this more moderate severity range, from 14 to 20 on the scale, in which there’s no question that doctors would likely consider prescribing medication,” Dr. DeRubeis said.

His co-authors included Steven D. Hollon and Dr. Richard C. Shelton of Vanderbilt University, Sona Dimidjian of the University of Colorado, Dr. Jan Fawcett of the University of New Mexico and Dr. Jay D. Amsterdam of Penn.

The effects of other popular S.S.R.I.’s like Lexapro and Prozac are not likely to be much different than those of Paxil, experts said."
Rebutting MSW

Columbus, OH

#34 Jan 6, 2010
MSW wrote:
If only newspapers wouldn't jump to conclusions...
If only people with Masters degrees wouldnt pretend to expertise they do not have.
Laura

Reynoldsburg, OH

#35 Jan 6, 2010
Ohio Lawyer wrote:
<quoted text>
Damn near nobody "claims they are depressed and gets money from taxpayers." You don't know a damn thing you lying ignorant schmuck.
You are wrong my friend. I know a family(related to my father)in Indiana that discovered this easy money and access to drugs galore-for almost free! They receive monthly SSID(D for disability) check that affords them section 8 housing and food stamps too.Just about every adult member of this family(and lots of their friends)is on SS Disability!
Woot

United States

#36 Jan 6, 2010
Columbus Reader wrote:
<quoted text>
You are clueless. It is often a chemical imbalance. Life situations can make it worse. Therapy can help, but it is not the only way to battle depression.
SSRIs (selective serotonin re-uptake inhibitors-anti depressants) relieve symptoms of depression by blocking the reabsorption (reuptake) of serotonin by certain nerve cells in the brain. This leaves more serotonin available in the brain. Increased serotonin enhances neurotransmission — the sending of nerve impulses — and improves mood. In addition, exercise can also be a great help by increasing endorphines into the brain. But it is often difficult for people who are depressed to even imagine getting off the couch let alone begin an exercise regime. Once the anti-depressant begins to work and the depression lessens, exercise becomes something do-able to these folks. Once free from depression they can also better "deal" with the issues in their life.
Or, this is absolutely no evidence that shows depression is caused by a chemical imbalance.

http://www.medicalnewstoday.com/articles/9935...

While serotonin levels can be lower in people with depression, it is believed that a depressed mood slows production of serotonin as it does with several other things (ie. white blood cells). There have been no studies done that show an organic cause of depression. The official cause of depression is listed in psych textbooks as "unknown".
Ohio Lawyer

Columbus, OH

#37 Jan 6, 2010
Laura wrote:
<quoted text>You are wrong my friend. I know a family(related to my father)in Indiana that discovered this easy money and access to drugs galore-for almost free! They receive monthly SSID(D for disability) check that affords them section 8 housing and food stamps too.Just about every adult member of this family(and lots of their friends)is on SS Disability!
No one gets Social Security Disability or SSI easily just because they have a diagnosis of depression. And anyone who thinks it's easy to get SSDI or SSI is a fool. You clearly are one.
because

Mount Hope, OH

#39 Jan 6, 2010
Ohio Lawyer wrote:
<quoted text>
No one gets Social Security Disability or SSI easily just because they have a diagnosis of depression. And anyone who thinks it's easy to get SSDI or SSI is a fool. You clearly are one.
Ohio Lawyer oughtta know.
Greyson
#41 Sep 25, 2013
I have ordered 2 times from this website PILLSMEDSHOP. COM . I called yesterday the customer care and asked for a discount as i was about to order twice the regular amount.
Local guy

United States

#42 Sep 25, 2013
Anti depressants has been proven to not work well in most cases. The offer little help to a very small percentage of people... This poison is pushed onto adults and children now. Sad!
Donte
#43 Oct 2, 2013
Very great deal and very smooth transaction. PILLSMEDSHOPdotCOM was on top of my order and shipped it within a day. Thats all that they have control over and they done it fast. It sat in customs for a little bit but they have no control over the sluggishness of how customs work.
Oliver Canterberry

Columbus, OH

#44 Oct 2, 2013
JMO wrote:
I am Bi-Polar and without my medication, which includes a mode stabilizer and two antidipressants, I would be hell to live with. I was diagnosed in June of 1988 and have still had some ups and downs every once in awhile. But the benefits I get for my Manic-Depressive illness is the best route to take. I have done counseling for years and it doesn't help my moods any. Medications for me is the best way to go.
Do you take Lithium for your bi-polar?

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