Analysis: Antidepressants do little f...

Analysis: Antidepressants do little for patients with mild or m...

There are 39 comments on the Columbus Dispatch story from Jan 5, 2010, titled Analysis: Antidepressants do little for patients with mild or m.... In it, Columbus Dispatch reports that:

Antidepressants do little more than sugar pills for patients with mild or moderate depression, according to a new analysis of six studies that included 718 people.

Join the discussion below, or Read more at Columbus Dispatch.

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Woot

United States

#2 Jan 5, 2010
Studies consistently show that placebos outperform medications 60-70% of the time. And people wonder why healthcare and insurance are so expensive.
Laura

Reynoldsburg, OH

#3 Jan 5, 2010
I always felt that people should ask themselves what is the root of their depression.Deal with what's causing it and depression will be gone!
Big Johnson

Columbus, OH

#4 Jan 5, 2010
I'm so bummed about this that my formerly moderate depression is now severe.

Maybe now those drugs will work!
Flush Obama

Windsor, CA

#5 Jan 5, 2010
Women will buy anything if they are told it will make them feel better. They use antidepressants three times as much as men. Wake up people! Don't be so damn gullible.

They needlessly feed the corrupt loser pharmaceutical companies billions of dollars each year.
SassyGrandma

Bellefontaine, OH

#6 Jan 5, 2010
Obviously, Laura, you have never suffered from read depression. People like you who don't accept depression as an illness really irk me. If you haven't walked in my shoes, keep your opinions to yourself.

Flush Obama - you should go jump in the cess pool yourself.
SassyGrandma

Bellefontaine, OH

#7 Jan 5, 2010
Excuse me ---- REAL depression
Uh Oh Dads Home

Marengo, OH

#8 Jan 5, 2010
Listen up you knuckleheads! If I have to come back in and her break up a fight you're ALL getting cut off.
MSW

Lewis Center, OH

#9 Jan 5, 2010
Too bad this study looked at two medications that aren't widely used by patients. Fluoxetine (Prozac) has shown really strong effectiveness in academic studies, especially with teenage depression, and similar studies have documented the effectiveness of other medications such as Zoloft and Paxil.

If only newspapers wouldn't jump to conclusions...
Really

Portsmouth, OH

#11 Jan 5, 2010
If you haven't suffered from any form of depression or lived/loved someone that has-please don't judge. It isn't a simple problem like get over it or deal with what is causing it-it isn't that easy. I wouldn't willingly chose to live with depression or wish it on someone else.
JMO

United States

#12 Jan 5, 2010
I am Bi-Polar and without my medication, which includes a mode stabilizer and two antidipressants, I would be hell to live with. I was diagnosed in June of 1988 and have still had some ups and downs every once in awhile. But the benefits I get for my Manic-Depressive illness is the best route to take. I have done counseling for years and it doesn't help my moods any. Medications for me is the best way to go.
Jack CA

United States

#13 Jan 5, 2010
Sassy grandma is right on the money. If you were a diabetic, you'd take insulin and not be criticized. Same holds true for not producing enough serotonin.
Ron

Silverado, CA

#14 Jan 5, 2010
MSW wrote:
Too bad this study looked at two medications that aren't widely used by patients. Fluoxetine (Prozac) has shown really strong effectiveness in academic studies, especially with teenage depression, and similar studies have documented the effectiveness of other medications such as Zoloft and Paxil.
If only newspapers wouldn't jump to conclusions...
The study included paroxetine, which is Paxil. They apparently used imipramine (Tofrani) as a representative tricyclic antidepressant, and paroxetine as a representative SSRI. This seems flawed to me, since individuals react differently to each antidepressant. For example, Prozac might work for one person, whereas another person benefits from Cymbalta but not Prozac. The range of TCA's affects norepinephrine and seratonin in differing ratios. Sinequan is heavy on serotonin, not norepinephrine, but Vivactil is the opposite.
Morning Coffee Man

Canton, OH

#15 Jan 5, 2010
I would give just about anything, to find out why it is that when I first started taking paxil, a tear ago, this time, it was working fine for me. Now, a year later, I am starting to feel the effects of it wearing off, and, I am suffering crying spells, and sadness. I'm taking 20 mg. of this stuff, along with Buspar, to control terrible anxiety attacks I was suffering this time, last year. What is a person to do?
double carafe

Mount Hope, OH

#16 Jan 5, 2010
Morning Coffee Man wrote:
I would give just about anything, to find out why it is that when I first started taking paxil, a tear ago, this time, it was working fine for me. Now, a year later, I am starting to feel the effects of it wearing off, and, I am suffering crying spells, and sadness. I'm taking 20 mg. of this stuff, along with Buspar, to control terrible anxiety attacks I was suffering this time, last year. What is a person to do?
Drink more coffee. It's the cure for whatever ails ya!
rebel

Columbus, OH

#17 Jan 5, 2010
Linda wrote:
That way if your so depressed you can't work, they will not acknowledge this and you won't get paid. It's all about the money$$$$$$
sooo many people do this: claim they are depressed, then they get money from taxpayers. It is unbelievable.
Jim

Columbus, OH

#18 Jan 5, 2010
MSW wrote:
Too bad this study looked at two medications that aren't widely used by patients. Fluoxetine (Prozac) has shown really strong effectiveness in academic studies, especially with teenage depression, and similar studies have documented the effectiveness of other medications such as Zoloft and Paxil.
If only newspapers wouldn't jump to conclusions...
WRONG- When you compare the studies done with the amount of improvement from the drug compared to the amount of improvement done with placebo. The therapeutic effect is less than 10% difference. Hence, in other words for example, Group A reports 45% report improvement on placebo, Group B report 55% improvement on the drug; the drug has a very small effect but is labeled statistically significant and marketed as "drug X decreases depression in 55% of patients" when in reality out of that 100% population it accounts for only 10% receiving a benefit. This has been known for years and actually is old news being revisited. Sorry if you have to sell your Pfizer stock.
Anonymous

Reynoldsburg, OH

#19 Jan 5, 2010
Morning Coffee Man--talk to your doctor to see if your meds need adjusting--sending good thoughts your way----been there and it's not easy.
Trent

Tampa, FL

#20 Jan 5, 2010
I live in USA and I suffer from anxiety a few years ago and I can not stop taking xanax since it helps me a lot to be able to relax and calm my impulses, in www.chronic-anxiety.com can find some medicine for anxiety.
Manchester

Tampa, FL

#21 Jan 5, 2010
The anxiety and the depression are the most common in these moments of distress and uncertainty in the world, many cases for the current consequences where there is no work and the little that is gained does not reach to solve the economic problems and this carries to that the people resort to tablets as valium, diazepam, xanax, to remove in them his depression, we hope that they solve as promptly as possible this situation since chronic-anxiety.com indicated in all the countries these medicines are most acquired and his sale grows rapidly.
Jane Doe

Columbus, OH

#22 Jan 5, 2010
Laura wrote:
I always felt that people should ask themselves what is the root of their depression.Deal with what's causing it and depression will be gone!
Hi Laura. Perhaps you could ask yourself what is the root of your insensitivity toward others. Deal with that and your uncaring ways will be gone!

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