Mutations in autism susceptibility ge...

Mutations in autism susceptibility gene increase risk in boys

There are 9 comments on the PhysOrg Weblog story from Jul 12, 2012, titled Mutations in autism susceptibility gene increase risk in boys. In it, PhysOrg Weblog reports that:

Researchers at Emory University School of Medicine have identified five rare mutations in a single gene that appear to increase the chances that a boy will develop an autism spectrum disorder .

Join the discussion below, or Read more at PhysOrg Weblog.

Since: Jan 07

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#2 Jul 13, 2012
The gene would be the cause, and vaccines a possible trigger. Accoeding to this study, rare variants in many different genes contribute significantly to risk for autism spectrum disorders.

Since: Jan 07

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#4 Jul 13, 2012
There's a difference between cause and trigger. That trigger could be environmental's like pesticides. This study is talking about predisposition of the gene.
That correlation/coincidence is about vaccines as a cause. Hate to burst your bubble, there still is no evidence vaccines could be a possible trigger and zilch evidence for vaccines being a cause.

Since: Jan 07

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#6 Jul 13, 2012
Actually that's incorrect. Aside from other genes implecated, you're forgetting this newest one, AFF2 gene which has nothing to do with vaccines.

Since: Jan 07

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#8 Jul 13, 2012
You're the only one who claims it. You prove it does have anything to do with vaccines.
Sam

Mascouche, Canada

#9 Jul 13, 2012
This mutation is so rare. It applies to 2 in 200 with autism.

How come they always want to pull a conclusion out of nothing.

What a waste, check your vaccines boozo...

Since: Jan 07

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#11 Jul 14, 2012
Nope. Never seen one may this or that in the article. But I did see this
"Tests showed that in four cases, the affected boys had inherited the risk-conferring mutations from their mothers. One boy had a "de novo" (not coming from the parents) mutation. Compared with X-linked genes in unaffected people, mutations in AFF2 were five times more abundant in the boys with ASDs."
Fragile X is inherited by the known FMR1 gene.

More than what can be said about vaccines. Now how about your proof?

Since: Jan 07

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#12 Jul 14, 2012
Sam wrote:
This mutation is so rare. It applies to 2 in 200 with autism.
How come they always want to pull a conclusion out of nothing.
What a waste, check your vaccines boozo...
"Recent large-scale genetic studies of autism spectrum disorders have identified several "rare variants" that sharply increase ASD risk. Scientists believe rare variants could explain up to 15 or 20 percent of ASD cases. However, until now no single variant has been found in more than one percent of ASD cases."

Key sentence there is until now no single variant has been found in more than one percent of ASD cases. It means more than what you think. It applies to 5 out of 202. And explains why more boys are affected since girls have a second copy of the gene where as boys do not.
That is a big deal finding.

Since: Jan 07

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#15 Jul 14, 2012
Then why are you wasting your time on this article? That's right. You dictate what people read. You're only here to name-call others.
Translation DUH

Winnipeg, Canada

#16 Jul 14, 2012
friend wrote:
Then why are you wasting your time on this article? That's right. You dictate what people read. You're only here to name-call others.
Its the only time we get to spend time together.

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