Copyright violation. You couldn't come up with that shit on your own? You had to google it? Really?Cannabinoid receptor
From Wikipedia, the free encyclopedia
CB1 and CB2 structures.
cannabinoid receptor 1 (brain)
NMR solution structure of a peptide mimetic of the fourth cytoplasmic loop of the CB1 cannabinoid receptor based on the PDB 2b0y coordinates.
Alt. symbols CNR
Locus Chr. 6 q14-q15
cannabinoid receptor 2 (macrophage)
Locus Chr. 1 p
The cannabinoid receptors are a class of cell membrane receptors under the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands, endocannabinoids (produced by the mammalian body), plant cannabinoids (such as THC, produced by the cannabis plant) and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and plant cannabinoids are lipophilic, i.e. fat soluble, compounds.
There are currently two known subtypes, termed CB1 and CB2. The CB1 receptor is expressed mainly in the brain (central nervous system, CNS), but also in the lungs, liver and kidneys. The CB2 receptor is expressed mainly in the immune system and in hematopoietic cells. Mounting evidence suggests that there are novel cannabinoid receptors that is, non-CB1 and non-CB2, which are expressed in endothelial cells and in the CNS. In 2007, the binding of several cannabinoids to a G protein-coupled receptor (GPCR) in the brain was described.
The protein sequences of CB1 and CB2 receptors are about 44% similar. When only the transmembrane regions of the receptors are considered, amino acid similarity between the two receptor subtypes is approximately 68%. In addition, minor variations in each receptor have been identified. Cannabinoids bind reversibly and stereo-selectively to the cannabinoid receptors. The affinity of an individual cannabinoid to each receptor determines the effect of that cannabinoid. Cannabinoids that bind more selectively to certain receptors are more desirable for medical usage.
Posted in the West Plains Forum
#64 Jun 24, 2012
#65 Jun 24, 2012
Ummm. Not a Neurologist. So blow me.
#66 Jun 24, 2012
back to the topic... it's a great idea and i think that you should be tested for any gov't handout, food stamps, welfare, medicade, unemployment, housing, all of it. you get 1 screwup and no more. after that your cut off.
#67 Jun 25, 2012
If you think thievery is bad now, cut everyone off any assistance they get because of "1 screw-up" and find out how desperate people can become. There won't be enough police to protect you from simply going to the store without having your house broke into the moment you leave and when you are walking out to your car with your groceries you would stand a greater risk of being robbed. Of course you could always arm yourself with a shotgun and start pulling the trigger anytime some one gave you an evil look, maybe even kill a couple welfare kids in the process. It may not be what you would want, but it may very well be what you end up with as a result.
If you make a dishonest person want something bad enough, chances are they won't obey the law to satisfy their hunger.
#68 Jun 25, 2012
it would be cheaper to employ more cops and after a period of time they will get the hint that if they need assistance they cant do drugs. cheaper for all in the long run. would be tough to inact but in the long run change is needed
#69 Jun 25, 2012
Do you pull cops out of thin air, wave your magic wand, say "Abra-cadabra" and make all the problems go away?
Where is this already over-taxed society we live in going to come up with the money to pay for these people to have a job?
If you think you can put people in jail over drugs, you need to wake up and see the reality of it all. Prisons don't have room or the budget for non-violent offenders. County jails don't have the space & budget either.
I think it's tragic that we live in a part of the country where you can find about 1 church for every mile of road you drive, yet the pious members of these churches want nothing to do with people who are misguided and really need the kind of help a church can offer. Instead of outreach, it's now become a personal qualification game. If someone lives in your neighborhood who has a few bad habits, local churches would rather write them off as sinners bound for Hell that can't be redeemed, so why waist your time on them, make the government punish them instead.
#70 Jun 25, 2012
Thank you for clearing that up and narrowing it down to illegal drug users. There for a moment I thought you might have been talking about alcoholics too. But this country has had plenty of experience with alcohol and we all know that never impacts a persons productivity or decision making process...at least not in this thread...this is only about drugs.
Having a bad drug habit is bad, but alcoholism doesn't hurt a thing?
#71 Dec 5, 2012
thats not nice
#72 Dec 5, 2012
I worked in fast food for a while and a lady i was working with cut her hand on a meat slicer she was so messed up she didnt feel a thing. I dont want people working around me all messed up on that stuff i am a truck driver and i promise you the last thing in the world you want is a truck driver on coke or meth or any other drug behind the wheel. If its not a problem for you than dont bitch or sue anyone if something happens to you or someone you know as the result of drug use.
#73 May 20, 2013
I'm not commenting to say my opinion on the topic but to break the 69 comments and make it 70
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