Premature Ejaculation: Treatment Is Nearing

Nov 21, 2009 Full story: Pravda 20

U.S. scientists made funny discovery which may help men to treat premature ejaculation - spray works as a drug.

Full Story
Jones

Beijing, China

#1 Dec 11, 2009
Now,A new Solutions:
EMLAAEROSOL: AN ON-DEMAND TREATMENT FOR PREMATURE EJACULATION
FOUNDED
Sexual dysfunction,
urinary incontinence and uro-gynaecology
BUSINESS MODEL
? Specialist sales and marketing unit in USA
? Establishment of proof of concept for products with pre-existing safety data followed by licensing to marketing and development partners
SUMMARY
EMLAAEROSOL is a proprietary, rapidly absorbed, formulation of two well established local anaesthetics, dispensed by a metered dose aerosol spray. Clinical studies indicate that EMLAAEROSOL can significantly improve ejaculation time in individuals with an established history of premature ejaculation (PE). EMLAAEROSOL is in Phase III clinical development.
PREMATURE EJACULATION
PE is the most common form of male sexual dysfunction. The condition is characterized by ejaculation within about one minute of vaginal penetration, and/or an inability to delay ejaculation on all or nearly all vaginal penetrations. Epidemiological studies indicate that between 25 to 30% of men of all ages will experience PE. The American Medical Association has estimated that approximately 20 million men in the US suffer from PE. Although a variety of medications are used to treat PE, none have regulatory approval for this condition and their efficacy and safety profiles are not satisfactory. PE can have a profound impact on quality of life and on personal relationships.
WHAT IS EMLAAEROSOL?
Penile desensitisation through the application of local anesthetics is an established therapy for PE, but available cream, gel and spray formulations are variable in effect, inconvenient to apply and are readily transferred to the partner. The EMLAAEROSOL formulation contains no solvents or oils and does not penetrate intact or fully keratinized skin. The metered dose delivery system allows a rapidly absorbed anaesthetic film to be precisely applied to the head of the penis. This avoids the need for a condom to protect the partner from product transfer.
EFFICACY
The results? of a placebo-controlled Phase II study in individuals with an established history of PE indicated that EMLAAEROSOL prolonged the mean intravaginal ejaculatory latency time (IELT), a standard measure of time to ejaculation, by over four times that of baseline IELT. Secondary study endpoints which included subject index of ejaculatory control, the sexual quality of life of subjects and their partners and the perception of prolonged time to ejaculation for subjects and their partners were also met.
Treatment
Subjects
Mean Baseline
IELT 1 (SE)
Mean Post-treatment
IELT 1 (SE)
Placebo
N=23
0.9 (0.15)
1.6 (0.33)
EMLAAEROSOL
N=20
1.0 (0.27)
4.9 (1.13)
The change from baseline in IELT was statistically significantly higher in the EMLAAEROSOL treated group compared with the placebo treated group (p<0.01)
Studies have demonstrated that the onset of action of EMLAAEROSOL is within five minutes or less and that the benefits last for at least two hours from dosing.
DEVELOPMENT STATUS
Two pivotal Phase III studies (one in the US and one in Europe, to run in parallel) were initiated in the fourth quarter of 2007. Each is a multi-centre, randomised, double blind and placebo-controlled efficacy study, with a total planned recruitment of 540 patients. The study endpoints include validated patient reported outcomes. Headline study data is expected towards the end of 2008.
LICENSING AND BUSINESS DEVELOPMENT
EMLAAEROSOL is a first in class, non-systemic treatment for PE, the most common form of male sexual dysfunction.
Jones

Beijing, China

#2 Dec 11, 2009
EMLAAEROSOL: AN ON-DEMAND TREATMENT FOR PREMATURE EJACULATION
Sexual dysfunction,
urinary incontinence and uro-gynaecology
BUSINESS MODEL
? Specialist sales and marketing unit in USA
? Establishment of proof of concept for products with pre-existing safety data followed by licensing to marketing and development partners
SUMMARY
EMLAAEROSOL is a proprietary, rapidly absorbed, formulation of two well established local anaesthetics, dispensed by a metered dose aerosol spray. Clinical studies indicate that EMLAAEROSOL can significantly improve ejaculation time in individuals with an established history of premature ejaculation (PE). EMLAAEROSOL is in Phase III clinical development.
PREMATURE EJACULATION
PE is the most common form of male sexual dysfunction. The condition is characterized by ejaculation within about one minute of vaginal penetration, and/or an inability to delay ejaculation on all or nearly all vaginal penetrations. Epidemiological studies indicate that between 25 to 30% of men of all ages will experience PE. The American Medical Association has estimated that approximately 20 million men in the US suffer from PE. Although a variety of medications are used to treat PE, none have regulatory approval for this condition and their efficacy and safety profiles are not satisfactory. PE can have a profound impact on quality of life and on personal relationships.
WHAT IS EMLAAEROSOL?
Penile desensitisation through the application of local anesthetics is an established therapy for PE, but available cream, gel and spray formulations are variable in effect, inconvenient to apply and are readily transferred to the partner. The EMLAAEROSOL formulation contains no solvents or oils and does not penetrate intact or fully keratinized skin. The metered dose delivery system allows a rapidly absorbed anaesthetic film to be precisely applied to the head of the penis. This avoids the need for a condom to protect the partner from product transfer.
EFFICACY
The results? of a placebo-controlled Phase II study in individuals with an established history of PE indicated that EMLAAEROSOL prolonged the mean intravaginal ejaculatory latency time (IELT), a standard measure of time to ejaculation, by over four times that of baseline IELT. Secondary study endpoints which included subject index of ejaculatory control, the sexual quality of life of subjects and their partners and the perception of prolonged time to ejaculation for subjects and their partners were also met.
Treatment
Subjects
Mean Baseline
IELT 1 (SE)
Mean Post-treatment
IELT 1 (SE)
Placebo
N=23
0.9 (0.15)
1.6 (0.33)
EMLAAEROSOL
N=20
1.0 (0.27)
4.9 (1.13)
The change from baseline in IELT was statistically significantly higher in the EMLAAEROSOL treated group compared with the placebo treated group (p<0.01)
Studies have demonstrated that the onset of action of EMLAAEROSOL is within five minutes or less and that the benefits last for at least two hours from dosing.
DEVELOPMENT STATUS
Two pivotal Phase III studies (one in the US and one in Europe, to run in parallel) were initiated in the fourth quarter of 2007. Each is a multi-centre, randomised, double blind and placebo-controlled efficacy study, with a total planned recruitment of 540 patients. The study endpoints include validated patient reported outcomes. Headline study data is expected towards the end of 2008.
LICENSING AND BUSINESS DEVELOPMENT
EMLAAEROSOL is a first in class, non-systemic treatment for PE, the most common form of male sexual dysfunction.
Jones

Beijing, China

#3 Dec 11, 2009
EMLAAEROSOL: AN ON-DEMAND TREATMENT FOR PREMATURE EJACULATION
Sexual dysfunction,
urinary incontinence and uro-gynaecology
BUSINESS MODEL
? Specialist sales and marketing unit in USA
? Establishment of proof of concept for products with pre-existing safety data followed by licensing to marketing and development partners
SUMMARY
EMLAAEROSOL is a proprietary, rapidly absorbed, formulation of two well established local anaesthetics, dispensed by a metered dose aerosol spray. Clinical studies indicate that EMLAAEROSOL can significantly improve ejaculation time in individuals with an established history of premature ejaculation (PE). EMLAAEROSOL is in Phase III clinical development.
PREMATURE EJACULATION
PE is the most common form of male sexual dysfunction. The condition is characterized by ejaculation within about one minute of vaginal penetration, and/or an inability to delay ejaculation on all or nearly all vaginal penetrations. Epidemiological studies indicate that between 25 to 30% of men of all ages will experience PE. The American Medical Association has estimated that approximately 20 million men in the US suffer from PE. Although a variety of medications are used to treat PE, none have regulatory approval for this condition and their efficacy and safety profiles are not satisfactory. PE can have a profound impact on quality of life and on personal relationships.
WHAT IS EMLAAEROSOL?
Penile desensitisation through the application of local anesthetics is an established therapy for PE, but available cream, gel and spray formulations are variable in effect, inconvenient to apply and are readily transferred to the partner. The EMLAAEROSOL formulation contains no solvents or oils and does not penetrate intact or fully keratinized skin. The metered dose delivery system allows a rapidly absorbed anaesthetic film to be precisely applied to the head of the penis. This avoids the need for a condom to protect the partner from product transfer.
Tim

Lexington, KY

#4 Jan 2, 2010
The facts are 1 in 3 men at some point in their lives experience some form of premature ejaculation. The root of the problem most likely stems from excessive masterbation. Due to excessive masterbation you have trained yourself to release your ejaculation as quickly as possible causing you to come within seconds.

The first step to ending premature ejaculation is to stop masterbating so much. I know masterbation is fun, but I promise longer lasting sex is MUCH better.

Checkout this ejaculatory training site that I found. It gives tips on how to control your ejaculatory reflex, allowing you to hold your ejaculation as long as possible. Its really helped me alot with my premature ejaculation, and its really helped things with my GF sexually. Hope it helps you.

curepremature-ejaculation .net
Busher

Jacksonville, FL

#5 Jan 8, 2010
Just tell her to suck a little slower. That will delay ejaculation.

Since: Dec 09

Sydney, Australia

#6 Jan 11, 2010
just one more fix of ............. it'll all be alright pheeeeew
Mike

Henderson, TX

#8 Jun 4, 2011
I can recommend a reputable pharmacy (Priligy) easytouserx.com/buy-priligy-usa.html... I recieved my pills within one week of ordering them.
P.S. 5% discount coupon code: 4y3g6f4k
George

London, UK

#14 May 24, 2012
Duramale for Premature Ejaculation - http://www.duramale.com/... Just wanted to write and say that I'm VERY satisfied with my purchase.
Christopher

Buffalo, NY

#17 Dec 12, 2012
I struggled with PE for years and years. Since my first encounters at the age of 16. I suffer from horrible pelvic muscles that reflex alot from my sensative penis. Even when I dont want them to causing PE. Most of all this was causing major depression and anxiety. I was scared to sleep with women. No man should have to deal with this. I know alot of men do. I probably go in about 2-3 minutes max , mostly around 1-2 minutes.
Some encounters I would have so much anxiety id go before i even entered. Luckily ive had many partners understand. I always feared women cared SO much about sex. But all in all they really are understanding. SO i tried Celexa an SSRI. This worked great for about a week. It slowed my sex drive and also gave me impotence. I didnt mind lol , i had so much drive i would eventually get up and have intercourse.
But this side effect only lasted for a week. All a sudden i was back to normal. So the doc put my on zoloft. This did nothing. So after being completley frustrated and having the taste of great sex for a week i search for Dapoxetine from http://menshealthpill.info/buy-priligy-usa.ht... .
I found it online overseas. i popped one at about 9 oclock and had intercourse about 11. I had sex for about 30 mins. I felt the urge to ejaculate for about a min then all of a sudden it was gone. Did not ejaculate at all! Lets just say i got her off 3 times. So next nite i did the same and had sex for an hour and half and still did not go! My new GF thinks im like a porn star.
SO next nite the same thing happens. She cant get me to cum what so ever. Miracle pill! Im on two weeks now of having multiple partners and making them orgasm. Still have not ejaculated. I can rub one off the next morning thats it! This better get approved by the USA!
Forster

France

#18 Feb 26, 2013
Before I tried priligy, I experimented with various 'herbal' miracle ointment, it really was a waste of time and if you really have a problem, it's not worth wasting your money. Since I've been using Priligy from http://pej-treatment.info , I've felt so much more in control of my sex life and would recommend it to anybody with a long term problem. I am not saying that it's a miracle cure, but I have noticed a definite improvement in how long I have been able to have sex for since using it.
Kennedy

São Paulo, Brazil

#19 Feb 26, 2013
i wrote:
Before I tried priligy, I experimented with various 'herbal' miracle ointment, it really was a waste of time and if you really have a problem, it's not worth wasting your money. Since I've been using Priligy from http://pej-treatment.info , I've felt so much more in control of my sex life and would recommend it to anybody with a long term problem. I am not saying that it's a miracle cure, but I have noticed a definite improvement in how long I have been able to have sex for since using it.
I received the order from this site and it was on time and the pills work great.
My special discount coupon code 1VQY12ZPi3
Orders under $150 are granted a 5% discount; orders above $151 are granted a 10% discount.
You can save your money.
Leapman

UK

#20 Apr 7, 2013
My first time I used Priligy from http://pej-treatment.info was very impressive, Priligy was working for me. I was able to keep it for about 8-9 minutes !!
Before I would usually last only for 3-4 minutes. Those 4-5 minutes were exactly what i needed to make my wife reach an orgasm. Few minutes can change your life.
i wrote:
I struggled with PE for years and years. Since my first encounters at the age of 16. I suffer from horrible pelvic muscles that reflex alot from my sensative penis. Even when I dont want them to causing PE. Most of all this was causing major depression and anxiety. I was scared to sleep with women. No man should have to deal with this. I know alot of men do. I probably go in about 2-3 minutes max , mostly around 1-2 minutes.
Some encounters I would have so much anxiety id go before i even entered. Luckily ive had many partners understand. I always feared women cared SO much about sex. But all in all they really are understanding. SO i tried Celexa an SSRI. This worked great for about a week. It slowed my sex drive and also gave me impotence. I didnt mind lol , i had so much drive i would eventually get up and have intercourse.
But this side effect only lasted for a week. All a sudden i was back to normal. So the doc put my on zoloft. This did nothing. So after being completley frustrated and having the taste of great sex for a week i search for Dapoxetine from http://pej-treatment.info .
I found it online overseas. i popped one at about 9 oclock and had intercourse about 11. I had sex for about 30 mins. I felt the urge to ejaculate for about a min then all of a sudden it was gone. Did not ejaculate at all! Lets just say i got her off 3 times. So next nite i did the same and had sex for an hour and half and still did not go! My new GF thinks im like a porn star.
SO next nite the same thing happens. She cant get me to cum what so ever. Miracle pill! Im on two weeks now of having multiple partners and making them orgasm. Still have not ejaculated. I can rub one off the next morning thats it! This better get approved by the USA!
Jacob

France

#24 Aug 8, 2013
http://inhousegeneric.com is an honest and genuine online pharmacy. We were not sure at first because this was our first order of generic medication from this pharmacy. Although it takes a bit long because it got stuck with custom, we are completely sastisfied with this online pharmacy.
You won't be disappointed with them. Their customer service is great too although they need to improve their phone system a bit more. If you need to call them just be sure to call during their working hours. Other than that we highly and sincerely recommend this online pharmacy to everyone.
James Jean

Huntington Beach, CA

#25 Aug 9, 2013
Try looking at Promescent. It’s a topical spray that is backed by the top urologists in the country. It has also appeared on the Dr. Oz show, and is approved by the FDA. www.promescent.com
Chaim

Romania

#26 Aug 17, 2013
Naturally, I am skeptical of everything online. http://inhousegeneric.com is legitimate. I placed my first order for the smallest amount possible. It arrived sooner than expected. I didn't pay the extra money for speedy air mail. I placed another order that was much larger and it came right on time. I will definitely use this company again for even larger orders now that I trust them. They also give you discounts every time you place an order which is cool. One thing to keep in mind is if you place a larger order, they will send half in one shipment, and then the other half after that to avoid customs scrutinizing your package. I am very happy, I no longer need to pay tons of money to see a doctor and therapist (and have them tell me a bunch of stuff I already know) in order to get my medication.
Garvy

UK

#32 Jan 29, 2014
I was in depression, I avoided sexual contacts. And I didn`t expect that Priligy could do something with my problem. But after the first intake of this medication from http://goo.gl/YU1mgT I noticed the positive results… Now I can say that I completely forgot about PE problem. My girlfriend is satisfied)))

Since: Jan 14

West Palm Beach, FL

#33 Jan 30, 2014
What i am saying is not a joke .Smoke some cannabis .It will make the sex so much more sensual with heightened sensitivity and it gives you the ability to control your body more .The most amazing erotic experience is with the herbs .This is not a pro Marijuana plug or nothing just sharing my experience
Greg

Sewickley, PA

#35 Feb 6, 2014
Priligy can work for PE but it's illegal in the U.S. and if you buy it, you have no idea what you're getting. Plus, too many side effects.

www.promescent.com is the way to go.
Bankster Raphan

Sarasota, FL

#36 Feb 6, 2014
Busher wrote:
Just tell her to suck a little slower. That will delay ejaculation.
..........bernie Madoff , Jonathan Pollard , Bill Kristol , Roger AILES , Mark Ciavarella , Gerald Garson , little farvel Alvin Jupiter and Greasy Thumb Gottlieb share a room at the AIPAC convention and the INFRAGARD Chamber of Commerce..........and these zionistas take their time..........they are on the FUSION CENTER Dole.
Ralph

Los Angeles, CA

#37 Feb 10, 2014
Check out the product Promescent. It is a product developed by Urologists and is rapidly becoming the treatment embraced by the medical community. It has an absorption technology that penetrates the top layer of skin and desensitizes the nerves in the penis. Promescent has no transference to your partner, allows the men retain sensation, is safe and easy to use. www.promescent.com offers a legitimate medical solution to those with PE or to those who would just like to prolong the experience

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