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“The one and only Smart Liberal”

Since: Aug 12

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#1
Apr 3, 2013
 

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One Drug to Shrink All Tumors

by Sarah C. P. Williams on 26 March 2012, 3:05 PM

A single drug can shrink or cure human breast, ovary, colon, bladder, brain, liver, and prostate tumors that have been transplanted into mice, researchers have found. The treatment, an antibody that blocks a "do not eat" signal normally displayed on tumor cells, coaxes the immune system to destroy the cancer cells.

A decade ago, biologist Irving Weissman of the Stanford University School of Medicine in Palo Alto, California, discovered that leukemia cells produce higher levels of a protein called CD47 than do healthy cells. CD47, he and other scientists found, is also displayed on healthy blood cells; it's a marker that blocks the immune system from destroying them as they circulate. Cancers take advantage of this flag to trick the immune system into ignoring them. In the past few years, Weissman's lab showed that blocking CD47 with an antibody cured some cases of lymphomas and leukemias in mice by stimulating the immune system to recognize the cancer cells as invaders. Now, he and colleagues have shown that the CD47-blocking antibody may have a far wider impact than just blood cancers.

"What we've shown is that CD47 isn't just important on leukemias and lymphomas," says Weissman. "It's on every single human primary tumor that we tested." Moreover, Weissman's lab found that cancer cells always had higher levels of CD47 than did healthy cells. How much CD47 a tumor made could predict the survival odds of a patient.

To determine whether blocking CD47 was beneficial, the scientists exposed tumor cells to macrophages, a type of immune cell, and anti-CD47 molecules in petri dishes. Without the drug, the macrophages ignored the cancerous cells. But when the anti-CD47 was present, the macrophages engulfed and destroyed cancer cells from all tumor types.

Next, the team transplanted human tumors into the feet of mice, where tumors can be easily monitored. When they treated the rodents with anti-CD47, the tumors shrank and did not spread to the rest of the body. In mice given human bladder cancer tumors, for example, 10 of 10 untreated mice had cancer that spread to their lymph nodes. Only one of 10 mice treated with anti-CD47 had a lymph node with signs of cancer. Moreover, the implanted tumor often got smaller after treatment—colon cancers transplanted into the mice shrank to less than one-third of their original size, on average. And in five mice with breast cancer tumors, anti-CD47 eliminated all signs of the cancer cells, and the animals remained cancer-free 4 months after the treatment stopped.

"We showed that even after the tumor has taken hold, the antibody can either cure the tumor or slow its growth and prevent metastasis," says Weissman.
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Weissman's team has received a $20 million grant from the California Institute for Regenerative Medicine to move the findings from mouse studies to human safety tests. "We have enough data already," says Weissman, "that I can say I'm confident that this will move to phase I human trials."

http://news.sciencemag.org/sciencenow/2012/03...
Bushwhacker

Kent, WA

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#2
Apr 3, 2013
 

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Stanford is a top notch school, but it's odd you're NOW in favor of Government funding.... Seems you're a convenient hypocrite...
non-starter

Burnsville, MN

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#3
Apr 3, 2013
 
Smart Liberal wrote:
One Drug to Shrink All Tumors
by Sarah C. P. Williams on 26 March 2012, 3:05 PM
A single drug can shrink or cure human breast, ovary, colon, bladder, brain, liver, and prostate tumors that have been transplanted into mice, researchers have found. The treatment, an antibody that blocks a "do not eat" signal normally displayed on tumor cells, coaxes the immune system to destroy the cancer cells.
A decade ago, biologist Irving Weissman of the Stanford University School of Medicine in Palo Alto, California, discovered that leukemia cells produce higher levels of a protein called CD47 than do healthy cells. CD47, he and other scientists found, is also displayed on healthy blood cells; it's a marker that blocks the immune system from destroying them as they circulate. Cancers take advantage of this flag to trick the immune system into ignoring them. In the past few years, Weissman's lab showed that blocking CD47 with an antibody cured some cases of lymphomas and leukemias in mice by stimulating the immune system to recognize the cancer cells as invaders. Now, he and colleagues have shown that the CD47-blocking antibody may have a far wider impact than just blood cancers.
"What we've shown is that CD47 isn't just important on leukemias and lymphomas," says Weissman. "It's on every single human primary tumor that we tested." Moreover, Weissman's lab found that cancer cells always had higher levels of CD47 than did healthy cells. How much CD47 a tumor made could predict the survival odds of a patient.
To determine whether blocking CD47 was beneficial, the scientists exposed tumor cells to macrophages, a type of immune cell, and anti-CD47 molecules in petri dishes. Without the drug, the macrophages ignored the cancerous cells. But when the anti-CD47 was present, the macrophages engulfed and destroyed cancer cells from all tumor types.
Next, the team transplanted human tumors into the feet of mice, where tumors can be easily monitored. When they treated the rodents with anti-CD47, the tumors shrank and did not spread to the rest of the body. In mice given human bladder cancer tumors, for example, 10 of 10 untreated mice had cancer that spread to their lymph nodes. Only one of 10 mice treated with anti-CD47 had a lymph node with signs of cancer. Moreover, the implanted tumor often got smaller after treatment—colon cancers transplanted into the mice shrank to less than one-third of their original size, on average. And in five mice with breast cancer tumors, anti-CD47 eliminated all signs of the cancer cells, and the animals remained cancer-free 4 months after the treatment stopped.
"We showed that even after the tumor has taken hold, the antibody can either cure the tumor or slow its growth and prevent metastasis," says Weissman.
.
.
.
Weissman's team has received a $20 million grant from the California Institute for Regenerative Medicine to move the findings from mouse studies to human safety tests. "We have enough data already," says Weissman, "that I can say I'm confident that this will move to phase I human trials."
http://news.sciencemag.org/sciencenow/2012/03...
The terminally slewpid poster makes a potentially feel good story about someone else's perceived political and financial tendencies. This would be a medical breakthrough on par with penicillin.
Bushwhacker

Kent, WA

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#4
Apr 3, 2013
 

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The hypocrites pretend they support public education, in an attempt to tie themselves to good news ????

COME ON, do personal attacks all you NEED, you hate FUNDING public education...

“The one and only Smart Liberal”

Since: Aug 12

Former MN Tax Payer

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Apr 3, 2013
 

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non-starter wrote:
<quoted text>The terminally slewpid poster makes a potentially feel good story about someone else's perceived political and financial tendencies. This would be a medical breakthrough on par with penicillin.
If this does prove to be successful, it would be on par with penicillin. Let's hope it happens.

Since: Sep 11

Rogers, MN

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#6
Apr 3, 2013
 

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non-starter wrote:
<quoted text>The terminally slewpid poster makes a potentially feel good story about someone else's perceived political and financial tendencies. This would be a medical breakthrough on par with penicillin.
This is not about public funding of education. It's about a potential cure for cancer. The grant they received was for further research and human safety trials, not education. While there is no mention in that story about private funding from a drug company, it also does not rule out that possibility.
Slewpid must hate cancer patients.
Awful Truth

Grantsburg, WI

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#7
Apr 3, 2013
 
Bushwhacker wrote:
Stanford is a top notch school, but it's odd you're NOW in favor of Government funding.... Seems you're a convenient hypocrite...
You Fauching Iddiot.

NOBODY in the world is against Researchers using Collective Funds to develop cures that improve human lives.

Only a Sheeple of your ilk could equate your Dependence on your Neighbors Wealth, to a researcher committing his life to curing disease.

I wonder what 17 Trillion Dollars coulda done for humanity if your Messiah had not stole it from our Grandchildren and bought the Sheeples Votes, and enriched his Mob Crony's?
Bushwhacker

Kent, WA

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#8
Apr 3, 2013
 

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This is a public university, it's MOSTLY publicly & partly privately funded... Without the public funding, breakthroughs like this wouldn't happen.
Awful Truth

Grantsburg, WI

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#9
Apr 3, 2013
 

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Bushwhacker wrote:
This is a public university, it's MOSTLY publicly & partly privately funded... Without the public funding, breakthroughs like this wouldn't happen.
Iddiot,

Without Collective interference in the Capitalist Marketplace no "Guberment Funding" would be required.

IF "We the People" desire cures for disease, we will pay for it.

The GOVERNMENT did not create these great people they were "born to greatness".....Without the Government, they no doubt would be even greater.

To illustrate;

You were "born to what you are" because your Mommy had sex with her Brother, your Uncle Daddy. Even if Uncle Daddy had never touched you and created the Sexual Anger you display 16/7, you still would have been "born to the piece of human garbage that you are".

Are we clear?.....ARE WE CLEAR!
Bushwhacker

Kent, WA

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#10
Apr 3, 2013
 

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The director of stem cell research at the Stanford University School of Medicine says he is troubled by draft guidelines issued today by the National Institutes of Health that would prohibit federal funding for research on stem cell lines created through a technique sometimes referred to as “therapeutic cloning” or somatic cell nuclear transfer.

Irving Weissman, MD, director of Stanford’s Institute for Stem Cell Biology and Regenerative Medicine, said the SCNT technique is one way to create disease-specific human embryonic stem cell lines on which to conduct research and test therapies. He also took issue with the assertion that the NIH consulted existing guidelines from the National Academy of Sciences and the International Society for Stem Cell Research—both of which sanction the use of SCNT-derived cell lines—in coming up with its draft recommendations.

“Instead of facts, the NIH placed its own version of ethics in place of the president’s clear proclamation,” said Weissman, the Virginia & D.K. Ludwig Professor for Clinical Investigation in Cancer Research.“As head of the National Academy of Sciences' panel that unanimously endorsed research using SCNT, and as a drafter of the guidelines for the International Society for Stem Cell Research, I know that this suggested ban on federal funding of SCNT-derived human embryonic stem cell lines is against our policies and against President Obama’s March 9 comments. The NIH has not served its president well.”

Since: Oct 08

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#11
Apr 3, 2013
 
Bushwhacker wrote:
Stanford is a top notch school, but it's odd you're NOW in favor of Government funding.... Seems you're a convenient hypocrite...
The Leland Stanford Junior University, commonly referred to as Stanford University or Stanford, is an American private research university located in Stanford, California on an 8,180-acre (3,310 ha) campus near Palo Alto. PRIVATE RESEARCH UNIVERSITY!!!!
Awful Truth

Grantsburg, WI

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#13
Apr 3, 2013
 
Bushwhacker wrote:
The director of stem cell research at the Stanford University School of Medicine says he is troubled by draft guidelines issued today by the National Institutes of Health that would prohibit federal funding for research on stem cell lines created through a technique sometimes referred to as “therapeutic cloning” or somatic cell nuclear transfer.
Irving Weissman, MD, director of Stanford’s Institute for Stem Cell Biology and Regenerative Medicine, said the SCNT technique is one way to create disease-specific human embryonic stem cell lines on which to conduct research and test therapies. He also took issue with the assertion that the NIH consulted existing guidelines from the National Academy of Sciences and the International Society for Stem Cell Research—both of which sanction the use of SCNT-derived cell lines—in coming up with its draft recommendations.
“Instead of facts, the NIH placed its own version of ethics in place of the president’s clear proclamation,” said Weissman, the Virginia & D.K. Ludwig Professor for Clinical Investigation in Cancer Research.“As head of the National Academy of Sciences' panel that unanimously endorsed research using SCNT, and as a drafter of the guidelines for the International Society for Stem Cell Research, I know that this suggested ban on federal funding of SCNT-derived human embryonic stem cell lines is against our policies and against President Obama’s March 9 comments. The NIH has not served its president well.”
Sociopath,

Great job!

Nobody can Google like you.

This cut/paste makes the "Folk" feel that you are a smart gal, right on top of the issues.....Not the Defective Child on the Playground of Life, who is envious of the Cool Kids that you spend 16/7 tossing rocks at.
scooby slew

Inver Grove Heights, MN

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#14
Apr 3, 2013
 
Niether of the Above wrote:
<quoted text>The Leland Stanford Junior University, commonly referred to as Stanford University or Stanford, is an American private research university located in Stanford, California on an 8,180-acre (3,310 ha) campus near Palo Alto. PRIVATE RESEARCH UNIVERSITY!!!!
Don't bother the slewchebag with facts, you ruin his preconceived notions. Why can't you just capitulate on his superior amount of stupidity like he wants?
scooby slew

Inver Grove Heights, MN

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#15
Apr 3, 2013
 
Bushwhacker wrote:
This is a public university, it's MOSTLY publicly & partly privately funded... Without the public funding, breakthroughs like this wouldn't happen.
We all remember you only pretend to know stuff slew. This is just another example of your pretending to know stuff.
Bushwhacker wrote:
I hope you pick stocks as well as you pretend to "KNOW" stuff ? Oh right, I do THAT !!! What do you do again ? Childish noises, right ?
Well, you at least admitted by your statement that you only pretend to know stuff. Shouldn't you be getting back to your whacking in the bushes?

There you go Slewby DooDoo, pretending to know stuff again.
Bushwhacker

Kent, WA

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#17
Apr 3, 2013
 
Funny, you cannot comprehend ...

I do that=I pick stocks..

Are you stupid or trying hard to reach that plateau ???
Bushwhacker

Kent, WA

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#18
Apr 3, 2013
 
Stanford is a top notch school, but it's odd you're NOW in favor of Government funding.... Seems you're a convenient hypocrite...

Since: Oct 08

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#19
Apr 3, 2013
 

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Post # 8
This is a public university, it's MOSTLY publicly & partly privately funded... Without the public funding, breakthroughs like this wouldn't happen.= LIE

Post 18

Stanford is a top notch school, but it's odd you're NOW in favor of Government funding.... Seems you're a convenient hypocrite... "The Leland Stanford Junior University, commonly referred to as Stanford University or Stanford, is an American private research university located in Stanford, California on an 8,180-acre (3,310 ha) campus near Palo Alto". PRIVATE RESEARCH UNIVERSITY!!!!- Another LIE!

That is 4 lies in less than 2 hours!!
Bushwhacker

Kent, WA

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#20
Apr 3, 2013
 

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The director of stem cell research at the Stanford University School of Medicine says he is troubled by draft guidelines issued today by the National Institutes of Health that would prohibit

**********FEDERAL funding**********

for research on stem cell lines created through a technique sometimes referred to as “therapeutic cloning” or somatic cell nuclear transfer.
Irving Weissman, MD, director of Stanford’s Institute for Stem Cell Biology and Regenerative Medicine, said the SCNT technique is one way to create disease-specific human embryonic stem cell lines on which to conduct research and test therapies.
CRASSUS

Green Bay, WI

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#21
Apr 3, 2013
 
Smart Liberal wrote:
<quoted text>
If this does prove to be successful, it would be on par with penicillin. Let's hope it happens.
Why? You don't feel we have enough people on the planet yet?
Bushwhacker

Kent, WA

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#22
Apr 3, 2013
 

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The director of stem cell research at the Stanford University School of Medicine says he is troubled by draft guidelines issued today by the National Institutes of Health that would prohibit

**********FEDERAL funding**********

for research on stem cell lines created through a technique sometimes referred to as “therapeutic cloning” or somatic cell nuclear transfer.
Irving Weissman, MD, director of Stanford’s Institute for Stem Cell Biology and Regenerative Medicine, said the SCNT technique is one way to create disease-specific human embryonic stem cell lines on which to conduct research and test therapies.

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