Aicar works in a very similar fashion as does resveratrol, the red wine extract. Researchers at several universities in the US and Europe over the past year have published multiple peer-reviewed studies in which Transmax resveratrol, a concentrated form of resveratrol used by researchers and physicians to study the effects of red wine extract, has been found to literally double physical endurance when ingested by mice. In addition the compound has increased their life span by 31% in a Harvard study done by Dr. Sinclair. Neither Aicar nor Transmax are substitutes for a healthy diet and regular exercise but they may help to ameliorate the adverse health effects of our sedentary lifestyle.