APA: Metabolic Risks Ignored in Choice of Atypical Antipsychotics

Full story: Psychiatric Times

Explain to interested patients that atypical antipsychotic agents have been associated with metabolic changes such as weight gain, dyslipidemia, and hyperglycemia.
Comments
1 - 5 of 5 Comments Last updated Aug 17, 2013
Margaret

Upper Marlboro, MD

#1 May 24, 2007
It is almost unbearable to read that my son's life could have been saved if these tests had been done and/or if he had had regular blood glucose tests. But in the Medicaid system, let alone in the "regular" health system, the primary care physician - or endocrinologist - does not collaborate with the psychiatrist. What a pathetic system of care we have.

I tried to have my son't psychiatrist's license taken away but the state medical board wouldn't consider it. They gave no reason. I guess they look out for their own.

“Watchtower Whistle-Blower”

Since: Dec 06

Bangor Maine USA

#2 May 25, 2007
Zyprexa promotion
Eli Lilly makes billions on diabetes treatment and also gets $4.2 billion a year in sales of their biggest cash cow Zyprexa which has been scandalized as *causing* diabetes as a major side effect.

(In 2004, the American Diabetes Association found that Zyprexa was more likely to cause diabetes than many other antipsychotic drugs.)

How does Zyprexa cause diabetes?

On July 1, 2002, Duke University issued a Press Release about the most recent finding that links the new anti-psychotics to early onset diabetes. The team of researchers--Elizabeth A. Koller, M.D. from the FDA, and Murali Doraiswamy, M.D. from Duke-- analyzed FDA's adverse drug report database, MedWatch (which receives 10% of adverse drug reports). They identified 289 cases of diabetes in patients who had been prescribed olanzapine (a.k.a. Zyprexa), Eli Lilly's most profitable drug.

The researchers reported:"Of the 289 cases of diabetes linked to the use of olanzapine, 225 were newly diagnosed cases. One hundred patients developed ketosis (a serious complication of diabetes), and 22 people developed pancreatitis, or inflammation of the pancreas, which is a life-threatening condition. There were 23 deaths, including that of a 15-year-old adolescent who died of necrotizing pancreatitis, a condition where the pancreas breaks down and dies. Most cases (71 percent) occurred within six months of starting the drug and many cases were associated with moderate weight gain."
End of Duke PR

So,it's "possible" that Zyprexa and the other atypicals may actually damage the pancreatic cells directly?

Scary thought! Daniel Haszard

“Watchtower Whistle-Blower”

Since: Dec 06

Bangor Maine USA

#3 May 25, 2007
So,it's "possible" that Zyprexa and the other atypicals may actually damage the pancreatic cells directly?
Fisher

UK

#4 Aug 1, 2013
I took Klonopin and Paxil for 15 years to treat my anxiety disorder. I had to detox from the Klonopin this past spring. I got off the Klonopin and switched my Paxil to Lexapro (sex side effect issue). I am also a recovering alcoholic. My doctor did not want me on Benzo's anymore (says it increased alcohol cravings). I stayed on Lexapro only for 9 months, but my anxiety came back strong on just the Lexapro alone. I almost resorted to taking Xanax before I switched doctors. My new doc gave Zyprexa from http://z-olanzapine.com a chance. I am on my 7th day and I haven't felt this "normal" in 5 years. I take 5mgs at night and it has ended the "chatter" in my head, and removed my anxiety. Great medicine so far.
Donovan

Romania

#5 Aug 17, 2013
Naturally, I am skeptical of everything online. http://z-olanzapine.com is legitimate. I placed my first order for the smallest amount possible. It arrived sooner than expected. I didn't pay the extra money for speedy air mail. I placed another order that was much larger and it came right on time. I will definitely use this company again for even larger orders now that I trust them. They also give you discounts every time you place an order which is cool. One thing to keep in mind is if you place a larger order, they will send half in one shipment, and then the other half after that to avoid customs scrutinizing your package. I am very happy, I no longer need to pay tons of money to see a doctor and therapist (and have them tell me a bunch of stuff I already know) in order to get my medication.

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