How does Zyprexa cause diabetes?
It has been "theorized" that Zyprexa causes diabetes by poisoning the pancreatic beta cells causing them to die off?(if this is true then it's really scary stuff)
On July 1, 2002, Duke University issued a Press Release about the most recent finding that links the new anti-psychotics to early onset diabetes. The team of researchers--Elizabeth A. Koller, M.D. from the FDA, and Murali Doraiswamy, M.D. from Duke-- analyzed FDA's adverse drug report database, MedWatch (which receives 10% of adverse drug reports). They identified 289 cases of diabetes in patients who had been prescribed olanzapine (a.k.a. Zyprexa), Eli Lilly's most profitable drug.
The researchers reported: "Of the 289 cases of diabetes linked to the use of olanzapine, 225 were newly diagnosed cases. One hundred patients developed ketosis (a serious complication of diabetes), and 22 people developed pancreatitis, or inflammation of the pancreas, which is a life-threatening condition. There were 23 deaths, including that of a 15-year-old adolescent who died of necrotizing pancreatitis, a condition where the pancreas breaks down and dies. Most cases (71 percent) occurred within six months of starting the drug and many cases were associated with moderate weight gain."
[ This I do know ...that at my clinic in Bangor Maine the Doctors have stopped prescribing Zyprexa except as a temporary PRN for acute cases only.
WHY? for two reasons:
1) The reason they give it out at all is because it is a fine med where indicated for specific symptoms and does the job very well
2)They stopped it as daily maintenance because they believe in their own hearts that it is the worst offender over the other atypicals AND because their patients refuse to take it on account of all the bad Zyprexa PR