Dangers of Stopping Clopidogrel (Plavix) for Patients with Sten...

Mar 16, 2006 Read more: Med Ad News 260
BETHESDA, Md., March 16, 2006 /PRNewswire/ -- Recent media reports regarding the results of the CHARISMA Trial may be misinterpreted by patients with coronary stents and other conditions*, causing these ... Read more
Neil

Urbana, IL

#21 Oct 11, 2006
Peter wrote:
I would like to know if anyone can clarify how long plavix should be taken with aspirin after stent placement.
The VA has issued the results of a report that said
that aspirin-only users did better after two years than the patients who took both aspirin and plavix.
Anyone have any input on this?
I was told by my VA physician that Plavix was no longer necessary but my cardiologist (non-VA) said that I should continue to take Plavix. He said the VA is misreading the study. I have a drug-coated stent and he feels that the use of Plavix should continue indefinately. He wrote to the VA but they said they are not going to change their position. Kind of leaves you and me between a rock and a hard place. Maybe a letter to our federal legislators might help.
Doctor Poser

Oakley, CA

#22 Oct 22, 2006
Dang Jacci, why heart problems at 21? I thought i was young. I dont have heart problems like most of you, I do have hypertension. Servere. I am on 2 pills of Diovan a day. I have to take it for the rest of my life. even forgetting to fill it and going 3 days without it, My blood pressure shot up and I felt like passing out several times and had a severe headache. What is Plavix for anyways? Is it like trycore for reducing blood fat or is it for high blood pressure?
Rich

North Easton, MA

#23 Oct 22, 2006
Neil wrote:
<quoted text>
I was told by my VA physician that Plavix was no longer necessary but my cardiologist (non-VA) said that I should continue to take Plavix. He said the VA is misreading the study. I have a drug-coated stent and he feels that the use of Plavix should continue indefinately. He wrote to the VA but they said they are not going to change their position. Kind of leaves you and me between a rock and a hard place. Maybe a letter to our federal legislators might help.
This seems like a typical VA cost savings measure at the patients expense.
Bill

Niantic, CT

#24 Oct 27, 2006
I had a drug-eluting stent inserted in January '06. VA supplied Plavix for 9 months. When I tried to have the Rx renewed, the VA Doc said they are only allowed to supply it for a 9-month period but are "studying it". Meanwhile, my non-VA Cardiologist wants me to stay on Plavix/Aspirin, indefinitely. So my monthly cost goes from $8 to $130. Gosh, that's 260% of my monthly income in WWII (before deductions)! Just may have to take out a Medicare D plan.
telboy

Portimão, Portugal

#25 Oct 27, 2006
Gail wrote:
<quoted text> I also suffer from atrial fibrulation..but my doctor has me on coumadin the past 2 years..she tells me that plavix is not as good for atrial fibrulation..I suggest asking more questions on this..I also take 81 mg. asprin daily
coudamin and plavix act differently. for fibrillation you should take coudamin, for stent plavix and sometimes 75mg aspirin as well
Neil

Urbana, IL

#26 Oct 28, 2006
To: Rich, Peter and Bill:
This situation with the VA and Plavix is very worrisome. Several noted cardiologists so are concerned about restenosis (abnormal cell growth within stents) that they are recommending the use of Plavix (for drug eluding stent patients)indefinitely until more is known about the overall risk of restenosis. For example, Dr. Salim Yusuf, Director the the Population Health Research Institue at McMaster University, Ontario, stated "...until we have more data, I would recommend aspirin and Plavix indefinitely."
The CHARISMA study is being misread by the VA but as Rich said is is a "cost cutting measure." Each of us should write to the VA or your elected federal representative to complain about the VA's interpretation of the CHARISMA study. In the meantime you may be able to buy a generic clopidogrel from Canada but a recent law suit by Bristol-Meyers will limit this drugs availability.
Regards,
Neil
Barry

AOL

#27 Nov 2, 2006
I am on Plavix for 4 years now with Bayer Asprin 325 mg 's i recently went under a Endoscopy and they made stop taking the Plavix & Asprin and when i did for 7 days i for once felt alot Better But i am on because of Heart disease So my Cardio tells me i have because of High Cholesterol which i take Vyotrin for that ...but i also had 4 stent put in ... they told me i had a Mild Heartattack back on 8/25/02 but now i feel a lot worse < physicaly> then i did ever before i think these heart drs take these Medications to seriously and ever since that News About what Plavix can do to you ...i suffer froom Anxiety Just because of that fear HMMM? Who shall i sue?
Andrew

Peakhurst, Australia

#28 Nov 16, 2006
Julie from Missouri wrote:
Please be very careful on the drug Plavix. Especially if you are taking it in combination with aspirin. I think that it is certainly being over prescribed in cases where it should not be. The drug may be beneficial to those who have a "history" of blood clots. However, those who do not, may be risking thier life. This is not a joke. Unfortunately, I have discovered this the hard way. My father who was a very active individual and reasonably healthy was taking Plavix to "prevent" the type of stroke caused by a blood clot. Unfortunately, three months after beginning the drug my father died suddenly of a massive hemorrhage in the brain.(No history of aneurysm or any other bleeding disorders.) The Plavix disabled his body from clotting and the damage was done to his brain before the surgeons could fix it. Was Plavix the cause??? You tell me...because the doctor's are unable to give me any explanation or cause.
<quoted text>
Hi Julie,

I am sorry to here your story. I do tend to prescribe plavix regularly but only for secondary prevention.
CHARISMA study was released early this year which showed that it shouldnt be given to a patient who has not had a previous stroke or heart attack
Andrew

Peakhurst, Australia

#29 Nov 16, 2006
Saleh,

I hope you are aware that plavix is not indicated for a.fib.
SALEH wrote:
<quoted text>
can you mention why are you taking it? who prescribed it to you? this is extremly important! my father has "A. fib." and he is taking plavix and I wouldnt risk even missing one dose!!! of plavix ( in his case)
echotech

Wayne, NJ

#31 Nov 22, 2006
Hi everyone,
I work in a cardiology office and I see so many people with the same questions and concerns that all of you have. Any time you take a drug there are certain concerns and risks and they should be disscussed throughly with your cardiolist. Medications like plavix, coumadin, ASA should really be considered before taking it, however those who have had cardiac intervention, atrial fibrillation or history of clots should, in most causes, be on it as the risk is out weighted by benifit. Our patients who have atrial fibrillation are usually on coumadin and they get there PT checked all the time. Atrial fibrillation causes clots to form in the heart and there a few patients in our office that refuse to take it. 2 of those patients have clots in there left ventricule. It scares me to know that these patients are walking around without taking blood thinners. On the other hand there is always a risk in severely bruising and bleeding. The only thing I can say is, trust your doctor.
Jamie

East Setauket, NY

#32 Nov 26, 2006
Hi Julie,

I am sorry to here your story. I do tend to prescribe plavix regularly but only for secondary prevention.
CHARISMA study was released early this year which showed that it shouldnt be given to a patient who has not had a previous stroke or heart attack....

Andrew...I had 4 stents, one RCA and three CX's. I didn't have a heart attack and all echo/stress testing indicates my heart is strong..{ex-marathoner]. I am on plavix 75mg, lo-pressor 25mg 2x a day. 325mg asprin.
I also take crestor 5mg...zetia 10mg and 100mg of CoQ10.
I power walk, and eat as close to a no cholesoral diet as possible, A wide mix of fruits, whole grains and drink tons of water.
I have mild side effects...back, bruising etc...nothing major.
If I read to much into all the side effects of the above drugs it kinda freaks me out. my LDL is down to 90, HDL's at 44...trigylcerates are right in the middle [good]. I quit all alcohol consumption and that has helped alot with my liver emzyens levels.
The major problem I have right now is I had quit smoking right after my surgury and stopped for four months, I started up again...I gotta knock it off or my doc's gonna kill me.

I'm probubly still kicking due to all the running I did in my 20's...30's and 40's. I used to run out of fear of heart attacks as my father died at 38 and my brother at 32. My brother had a genetic malfunction where the liver emzene for controlling lipids in his liver was missing.
I guess I'm lucky I made it to 50 before getting my stents.
JOHN ATCHLEY

AOL

#33 Dec 9, 2006
Peter wrote:
I would like to know if anyone can clarify how long plavix should be taken with aspirin after stent placement.
The VA has issued the results of a report that said
that aspirin-only users did better after two years than the patients who took both aspirin and plavix.
Anyone have any input on this?
Hi, I had a heart stint put in in July 2006. My Dr insist I take Plavix and an asprin a day for a year. He said it used to be 3 months but now he thinks a year is the proper time frame,
Deb

Auburn Hills, MI

#34 Dec 18, 2006
My husband was diagnosed with a precancerous cell condition in his esophagus a year ago. He was placed on Nexium. Six months ago he began experiencing a burning in his chest. After months of self-healing remedies, he went to the doctor again. His doctor sent him to have a stress test which resulted in immediate hospitalization and three stents. Unfortunately, he still has the burning in his chest which is supposedly not heart related. We actually sent to the doctor initially to get another endoscopy (before the heart incident). Since my husband is on Plavix and the cardiologist will not take him off, the gastroenterologist will not do the endoscopy and the family doctor is stuck in the middle of both of them. In the meantime, my husband's precancerous condition (which we are hoping is not turning cancerous) is put on hold for six months. We all know that esophageal cancer spreads rapidly, but we are told we have to wait. Is there no way to do an endoscopy and be able to biopsy tissue without being taken off Plavix. I can't believe my husband is the only person who has a serious esophageal condition and is also on Plavix. Any help would be greatly appreciated. Thank you.
Deb

Auburn Hills, MI

#35 Dec 18, 2006
My husband just had stents and his doctor told him at least six months, if not a year. He is also on 81 mg aspirin.
Aaron

Dallas, TX

#36 Jan 13, 2007
My mom has no history of heart nor stroke problems. she cut her knee 12-16-06 i took her to the e.r. and she came home with plavix 75mg and asprin 81mg. she bled for 3 days and had to have a blood transfusion, she also experienced headaches, brusing, nose bleed, fatique, weakness. i am mad as hell at this as she is 81 years old. i want the makers of plavix to pay my mom $1 billion dollars for hurting her. and another billion from the quack who prescribed it to her. dallas, tx.
Lenny-Pa

United States

#37 Jan 19, 2007
At the age of 54 I had a heart attack and had a stent placed I was put on Plavix TopralXL lisinaprel and asperin 325mg. I had never taken anything stronger than a tylenol in my life. One month later I had what I thought was the flu. After passing out on the livingroom floor I was rushed to the ER. I had a major GI bleed requiring blood transfusions. The Plavix and ASA was stopped for one month then I was started on Plavix again but I am not to take any form of ASA again. I take only tylenol there is ASA in most pain relievers! So if you are on the heart coctail be very careful of what you take. Motrin Ibprofin contain ASA! So if you take them you are over dosing yourself. This was two years ago and no more bleeding. So if you are on ASA be careful!
Kathy

United States

#38 Jan 24, 2007
Hello
My dad was 68 when he passed on Nov 16 2005. In august 2005 he had a pacemaker inserted. The doc put him on warfarin and plavix. Within 3 months my dad died from a massive brain bleed. I feel like killing the docs and drug mfg. They killed my dad as far as I am concerned. He loved life and they took it from him. God will give them what they deserve. I cry everyday. He believed everything the heart doctors told him. We called the doc in Oct 2005 to tell them that dad was dizzy all the time and they said to keep taking the meds as prescribed. He wasnt overweight and he ate a healthy diet and exercised. I called a lawyer but i cant relive the pain the docs have caused us. No amount of money will reverse what they did. I dont trust any dr or medications. If your not rich then your health care wont be at its best. If my dad was a senator he would still be alive. This world disgusts me.
Julie from Missouri

Barnesville, OH

#39 Jan 29, 2007
Kathy,
I hear & feel your pain. The situations with our Dads is so similar it makes me nauseated. We blindly trusted as well. We believed "take the drugs just like the doctor said, eat right, exercise & everything would be okay". Then, out of nowhere we were blind-sided with the completely unexpected. More and more of these stories are coming out and only the names have changed. I assure you that there are people out there just like us...I've personally spoke with many. We should actually start our own support group. I also assure you that there are people out there who are looking into this. It's too late for us...but not for the many others. All I can say to the many others who don't believe the drug is dangerous is...please listen to your body. Report any unusual symptoms IMMEDIATELY...especially headaches, dizziness, nausea and blurred vision (& any other signs of abnormal bleeding). This drug cannot be reversed except with the transfusion of platelets. May God bless you, Kathy, and bring you peace. This will work itself out eventually.
Kathy wrote:
Hello
My dad was 68 when he passed on Nov 16 2005. In august 2005 he had a pacemaker inserted. The doc put him on warfarin and plavix. Within 3 months my dad died from a massive brain bleed. I feel like killing the docs and drug mfg. They killed my dad as far as I am concerned. He loved life and they took it from him. God will give them what they deserve. I cry everyday. He believed everything the heart doctors told him. We called the doc in Oct 2005 to tell them that dad was dizzy all the time and they said to keep taking the meds as prescribed. He wasnt overweight and he ate a healthy diet and exercised. I called a lawyer but i cant relive the pain the docs have caused us. No amount of money will reverse what they did. I dont trust any dr or medications. If your not rich then your health care wont be at its best. If my dad was a senator he would still be alive. This world disgusts me.
Trish

New Brunswick, NJ

#40 Feb 7, 2007
Hello,
My father had a stenting done on his carotid artery, a procedure pushed by his cardiologist, and was blinded by a stroke to his eye during the procedure. He then had the carotid artery on the other side surgically cleared and everything was fine. If only he had done the surgery he would still be able to see. Now almost two years later the VA hospital tells him he should stop taking plavix, his cardiologist tells him to keep taking it. Who should we trust? I want to tell my dad the right decision but I don't know what it is.
Joe

Green Bay, WI

#41 Feb 8, 2007
I'm 53, and did not even know I had a heart attack until I had a stress test. A 155 Cholesterol level, average weight, and 5 Taxus stents for a 95% blockage.
Had bladder cancer in 2003, and now have an large incisional hernia and epipdidymitis which is requiring surgery to repair the hernia dn remove the epididymis.
Cardiologst, surgeons agree that continuing the Plavix and 325 Aspirin is not a significant risk factor, as most surgeries use a cauterizing knife that reduces bleeding.
I have no fears or concerns about the Plavix and surgery, even though until recently it was recommended to stop it.
The Cardiology Assoc, the JAMA and Lancet all agree that Plavix should not be stopped until at least one years therapy has been completed, as the tissue growth at the stent sites could create a clot within a couple of days.
Horror stories, in here and elswhere, do not often tell the whole story. Many people have had bleeding ulcers that they did not get treated or tell their doctors about. Many smoke and lie to the docotrs about that. And the worst is that family and friends often know about the bad habits and conditions and do little or nothing about it. Deaths are often not just one cause.
It is a combination of many things.
In my case, being as young as I am, the 30 years I smoked was a likely culprit. Since my cancer I have gained nearly 30 lbs from inactivity. My cystoprostatectomy with illeal neobladder reconstruction has created other conditions, such as acid reflux and short gut syndrome limiting my activity and significantly changing my lifestyle.
I understand this is a major surgery so quickly after the stents. 7 months, but the hernia is bad, and the risk of sepsis from the epididymitis is too high.
I have the them scheduled for next week, and will stay one extra day to watch the bleeding and my heart's response to surgery.
One thing is that I did my online research at JAMA, medical colleges, searched for clinical trials, here and abroad to find out my risks, the procedures and the best science on the issues.
I avoid the opinion forums, like this, as little can be garnered of fact to make a wise decisions. Opinions are OK, but have to be taken with a grain of salt.
The science out there is what everyone needs, more than a shoulder.
I wish everyone luck and advise to not chane any medications, especially Plavix therapy unless tests can prove you should.
Let science lead you, not emotional driven opinions.
Get two, three or four opinions...ask questions, ask for medical articles, studies anything you want to inform youself.
You will not find any doctor who will deny you information.

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