drinking water issue in Middleboro
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drinking well

Malden, MA

#29 Dec 8, 2008
the topic just opened again.

The wells are to shallow in Middleboro
Well water issue

Malden, MA

#30 Dec 9, 2008
Does anyone care ?

Please ask questions

Plymouth doesn't have any problems
well water

Malden, MA

#31 Dec 10, 2008
we will have to do a petition and send it to the DEP
well water

Malden, MA

#32 Dec 10, 2008
We are gong to notify the EPA
Less Nosy Neighbor

Cambridge, MA

#33 Dec 11, 2008
Just do it and shut up. You threaten but never follow through. Just do it and move on.

After you notify Tom Riely at Region 1 about the issue, please post his response.
well water

Malden, MA

#34 Dec 11, 2008
who is tom riley at region 1 ?
Public Citizen

Malden, MA

#35 Jan 24, 2012
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http://www.jbc.org/cgi/content/full/279/31/32 ...

....
Oxidative stress is considered a major factor in the induction of the mitochondrial permeability transition (MPT)(12, 13). The MPT is a Ca+2-dependent process often associated with various other factors (14). The MPT is characterized by opening of the permeability transition pore in the inner mitochondrial membrane, resulting in increased permeability of this membrane to protons, ions, and other solutes 1500 Da. This increased permeability leads to a collapse of the mitochondrial inner membrane potential, colloid osmotic swelling of the mitochondrial matrix, defective oxidative phosphorylation, and cessation of ATP synthesis, ultimately resulting in mitochondrial failure (15). The MPT is characteristically blocked by cyclosporin A (CsA)(16).
Because manganese toxicity is associated with oxidative stress, a major inducer of the MPT, we examined the possible role of the MPT in the mechanism of manganese neurotoxicity. The MPT was assessed in cultured astrocytes and neurons after exposure to different concentrations of manganese acetate for variable time points.
...
Although mechanisms involved in the induction of the MPT by manganese are not known, manganese has been shown to induce oxidative stress. Manganese, being a transition element, is capable of existing in different oxidation states, including Mn2+, Mn3+ and Mn4+. The transitional shift of Mn2+ to Mn3+ could lead to increased oxidant capacity of this metal. Accordingly, recent reports indicate that Mn3+ was more toxic compared with Mn2+(35). Treatment of astrocytes with manganese increased free radical production and decreased the activities of key antioxidant enzymes, SOD and glutathione peroxidase (11). More recently, Zhang et al.(34) reported the increased production of free radicals in isolated rat brain mitochondria exposed to manganese, in addition to the inhibition of various electron transport chain enzymes....
In summary, we have shown that manganese preferentially induces the MPT in cultured astrocytes. Cultured neurons were far less affected by manganese exposure compared with astrocytes. The manganese-induced MPT was blocked by antioxidants, suggesting the potential involvement of oxidative stress in this process. Induction of the MPT by manganese and associated mitochondrial dysfunction in astrocytes may represent key mechanisms in manganese neurotoxicity.

we have to open this topic up again. The residents have to get mad.
Fed-up

Malden, MA

#36 Jan 25, 2012
the topic just opened again.

The wells are to shallow in Middleboro
matt

Middleboro, MA

#37 Feb 26, 2013
If I could add to this....Ed, you are from everett right? for those who don;t know, everett is almost 60 miles from middleboro, and there are 4 different water supplies between here and there.
second, all water in the united states are tested for POTABILITY once or twice a month. there is a minimum / maximum that all water has to meet for state and federal monitoring Per the EPA,DHHS,FDA as well as state and town water quality. EDDIE is the first and only person I have ever heard of saying anything about middleboro water being connected to any health issues ever! Oh yeah, middleboro water was voted best tasting water in the world by the Berkeley springs international water tasting association. And also, Queen Elizabeth III has middleboro shipped to England exclusively for her, and Donald trump as well. So if you want to talk [email protected] about something, do you're research so you don't sound like a total moron, and embarrass yourself

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