Nucleocapsid protein structures from orthobunyaviruses reveal insight ...

Jun 7, 2013 Full story: Nucleic Acids Research

We report the crystal structure of both the Bunyamwera virus N-RNA complex and the unbound Schmallenberg virus N protein, at resolutions of 3.20 and 2.75 A..., respectively.

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andrew j langham

Derby, UK

#1 Jun 11, 2013
best vaccinate with gamma interferone or HPV vaccine will prevent this virus in sheep and lambs
andrew j langham

Derby, UK

#2 Jun 11, 2013
Cellular responses to IFNγ are activated through its interaction with a heterodimeric receptor consisting of Interferon gamma receptor 1 (IFNGR1) and Interferon gamma receptor 2 (IFNGR2). IFNγ binding to the receptor activates the JAK-STAT pathway. IFNγ also binds to the glycosaminoglycan heparan sulfate (HS) at the cell surface. However, in contrast to many other heparan sulfate binding proteins, where binding promotes biological activity, the binding of IFNγ to HS inhibits its biological activity.

The structural models shown in figures 1-3 for IFNγ are all shortened at their C-termini by 17 amino acids. Full length IFNγ is 143 amino acids long, the models are 126 amino acids long. Affinity for heparan sulfate resides solely within the deleted sequence of 17 amino acids. Within this sequence of 17 amino acids lie two clusters of basic amino acids termed D1 and D2, respectively. Heparan sulfate interacts with both of these clusters.
In the absence of heparan sulfate the presence of the D1 sequence increases the rate at which IFNγ-receptor complexes form.
Interactions between the D1 cluster of amino acids and the receptor may be the first step in complex formation. By binding to D1 HS may compete with the receptor and prevent active receptor complexes from forming.
Langham virus Research

Manchester, UK

#3 Nov 16, 2013
the world needs air pasteurizers fitted to aeroplanes trains' offices' hospitals doctors waiting rooms; Hot air pasteurizers will kill H7N9 viruses dead; hot air pasteurizers have an electrical heating element in side very long pipes which can be flexible to save space' germs virus and spores can be heated and killed' the pipe over all length is important' the piping has to be sufficient length to give sufficient heating time to kill all the viruses' dampening the initial incoming air helps kill the spores at a temperature of 300 degrees C plus; Andrew John Langham' I Love Jesus; He has helped me a massive amount;

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