Roche, ImmunoGen Bullseye Breast-Cancer Drug Wins Approval

Roche Holding AG and ImmunoGen Inc. won U.S. approval for a breast cancer therapy that's designed to narrowly target the disease. Read more

Since: Dec 05

Reading, PA

#1 Feb 22, 2013
In regards to response to anti-HER2 therapy after treatment with Kadcyla, I’ve heard from breast cancer patients who were bumped from the T-DM1 clinical trial because of disease progression, which meant that their cancer was growing despite the drug. Bumped off the trial because of disease progression? Wonder how many more patients there were like this?

Response rates (how much a tumor decreased in size) can be inflated when excluding patients during clinical trials (evaluable patients). Patients not considered “evaluable” are often those who do not get the benefit of an entire treatment plan. The response rate is calculated after removing patients, who die or have been excluded, from the calculation. This inflates the response rate.

But clinical oncologists want to publish their papers. They need to report on the outcomes of their experiments, but if they had to wait for survival data, it could take years until all the data was aggregated. That wouldn’t bode well for them to participate in pharma-sponsored trials in the future.

Response rates give clinical oncologists the opportunity to take a more optimistic look at therapies that have limited success. They can describe results as being complete remission, partial remission or simply clinical improvement.

If they treat all patients for three weeks, they can fairly evaluate the efficacy of a compound, which takes that lone (on average) before it can be regarded as effective. If they disregard all patients who die or were excluded after onset of therapy, and include only those treated three weeks or more, they can improve their data.

To justify their existence, they have to publish papers. That’s what they do.

http://cancerfocus.org/forum/showthread.php...

Tell me when this thread is updated:

Subscribe Now Add to my Tracker

Add your comments below

Characters left: 4000

Please note by submitting this form you acknowledge that you have read the Terms of Service and the comment you are posting is in compliance with such terms. Be polite. Inappropriate posts may be removed by the moderator. Send us your feedback.

Biotech Discussions

Title Updated Last By Comments
News Businesses: Indiana's gay discrimination is bad... 9 hr doty 79
News Neighbors Walk for Awareness Sun depressionman22 1
News Merck's mumps vaccine clinical tests were total... Mar 24 Vaccines Cause ADHD 13
News The Centers for Disease Control and Prevention ... Mar 21 Albert 2
Wooden Furniture For Sale In UK Mar 20 gaweakte 1
News Transgender teenager Jazz Jennings signed to be... Mar 18 Bikash 2
S.S.D. Chemical / Solution , CASTRO X OXIDE (Mar '12) Mar 16 Dr Abdullah Saleh 10
More from around the web