Kinase Inhibitors Could Keep Cancer Patients Alive For Much Longer
Kinase inhibitors, a class of cutting-edge cancer medications, could keep patients alive for far longer than is currently possible after scientists from the University of Sussex and The Institute of Cancer Research, England, discovered how they attack tumors.
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Since: Dec 05
#1 Mar 19, 2013
High doses of kinase inhibitors
According to laboratory oncologist Dr. Larry M. Weisenthal, high dose pulse Kinase inhibitors can be effective for central nervous system (CNS) disease, so long as resistance has not developed.
His Weisenthal Cancer Group has been testing erlotinib, lapatinib, sorafenib and vemurafenib, along with about eight other kinase inhibitors, in actual human tumor primary culture micro-spheroids (microclusters), in various cancers.
He has often recommend higher dose, pulse/intermittent therapy, in combination with other agents. These drugs are not identical, however. Some work in some tumors, while others do not -- yet in other tumors, the drugs which didn't work do work and vice versa.
You'd think that if they all had the identical mechanism of action that they'd all work or they'd all not work; but that's not the way it goes. It may have something to do with entry into the cell; efflux out of the cells; inactivation, or whatever. It does show that there's much more to the action of a drug than simply the presence of a "target" molecule.
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