How about one last flight of KC-135 Tankers loaded with pigs blood spraying a swath from Iran to Yeman.
It won't destroy Islam (That is a religious concept, a belief and political system.) Nor would I say do a genocide or ethnic cleansing on all Muslims.
But spraying Mecca, esp during the Haj when you have about 3 million of them in one place at one time, should send them a message they'd never forget.
Statistically there are more U.S. Muslims than Saudi Muslims. Indonesia has the largest collection of Mohammad Koran reading believers. In all, over 178 million followers. Perhaps just on drop of pig blood put on the tip of each bullet round used in battle would be better.(No sense in Damning any innocent Muslims.) That'd make each Muslim killed with a pig blood poisoned bullet damn to hell, and unable to get into paradise. Consider it a specialized ordnance for Islamic enemies.(Call Halliburtin, and request a special order!)