Ray McDonald News

San Francisco 49ers linebacker Takeo Spikes is questionable for Sunday's game at Indianapolis with a shoulder injury.

Jim Caldwell continued his dispassionate march into the NFL record books. Sunday's 18-14 win over the San Francisco 49ers pushed the Colts' record -- and Caldwell's -- to 7-0. He's just the third rookie coach in league history to open a season 7-0, the first since Potsy Clark of the Portsmouth Spartans opened 8-0 in 1931.

The numbers were out of whack and certainly not up to the normal lofty standards set by Peyton Manning and the Indianapolis Colts offense.

After losing their first game of a five-game stretch, the 49ers face their toughest opponent of the season as they hit the road to face the Indianapolis Colts.

We've got the final injury report for the week, but there remain a lot of question marks.

Takeo Spikes #51 of the San Francisco 49ers heads downfield against the Green Bay Packers during a preseason game on August 16, 2008 at Candlestick Park in San Francisco, California.

The 49ers had an earlier-than-normal Friday practice today because they are flying off to the eastern time zone later this afternoon.

The 49ers will keep an eye on thrice-concussed safety Michael Lewis another week.

He sustained his third concussion since Aug. 18 in the Atlanta game on Oct. 11. A concussion to linebacker Jeff Ulbrich compelled the 49ers to place the 10-year veteran on injured reserve, but Lewis' status is week-to-week. "I think it's a matter of continuing to talk to the doctors and trainers and what's really best for him," coach Mike ...

We've got the final injury report for the week and we have official word that Michael Lewis is out.

28, he seemed to be coming to a team in need of his talents after spending the first four years of his career with the Tennessee Titans.

The 49ers and Texans have released their injury reports for Wednesday. 49ers OUT S Reggie Smith LIMITED IN PRACTICE CB Tarell Brown , S Michael Lewis , DE Ray McDonald FULL PARTICIPATION RB Frank Gore , CB Marcus Hudson Texans DID NOT PRACTICE LB Brian Cushing , S Nick Ferguson FULL PARTICIPATION K Kris Brown , LB DeMeco Ryans Both head coach Mike ...

Lewis, who sustained two concussions during an 11-day span in the preseason, could be sidelined for a prolonged period.

' condition is by far the most troubling since he sustained his third concussion since Aug.

Walker returns kick to the 17 ... Hill finds room, passes to Morgan for 12 yards ... Hill hits Walker for 39 yards ... 1st and 10 from ATL 32 ... 1st and 10: Coffee runs for two ... 2nd and 8 from 30: Nobody blocks DE, Hill has to throw the ball away ... Hill inc.

The San Francisco 49ers ' leader knows he lost his cool. Mike Singletary became so frustrated with his team's poor play he couldn't help himself but to verbally respond to former 49er Harvey Dahl when the offensive lineman engaged the coach near the San Francisco sideline with Atlanta driving downfield again.

With the Michael Crabtree contract finally signed, Deion Sanders opened up Sunday about his connection to the 49ers' first-round draft pick and the prolonged negotiations.

Hill was forced to throw it away when a rusher came free off the right end. Then Joe Nedney missed a 46-yarder. Not a good sign for a stirring comeback.

Jaymee Marty of Sacramento is an ecologist, science writer and nature photographer.

The San Francisco 49ers are playing some of their best defensive football of the past decade, and it's just about the entire unit that's doing it.