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Novel two-drug maintenance combination works at least as well as...
An oral combination therapy of two antiretroviral drugs, the non-nucleoside rilpivirine and the new integrase inhibitor GSK1265744 , was at least as effective as a standard nucleosides-plus-efavirenz triple combination in keeping viral load undetectable in people taking it, the 21st Conference on Retroviruses and Opportunistic Infections heard on ... (more)
Merck's Investigational HIV Therapy, Doravirine (MK-1439),...
Merck , known as MSD outside the United States and Canada, today presented data from the dose-ranging portion of an ongoing Phase 2B clinical trial of doravirine, the company's investigational next-generation, non-nucleoside reverse transcriptase inhibitor , at the 21st Conference on Retroviruses and Opportunistic Infections .
HIV and Hepatitis
CROI 2014: Faldaprevir + Interferon Cures HIV/HCV Coinfected People
The hepatitis C virus protease inhibitor faldaprevir added to pegylated interferon and ribavirin cured nearly three-quarters of genotype 1 HIV/HCV coinfected patients in the STARTVerso4 trial, equaling response rates for people with HCV alone, according to a report this week at the 21st Conference on Retroviruses and Opportunistic Infections in ... (more)
Featured on the Blogs: Why Lower-Dose Efavirenz Will Make the Sun Shine Brighter
The HIV antiretroviral efavirenz works just as well at 400 mg as at 600. Paul Sax says that this "will make treatment cheaper, coformulations easier, the pills smaller, and the sun will shine brighter, too."
Unusual New HIV Drug Resistance Mechanism Revealed
WASHINGTON D.C. Feb. 18, 2014 -- For the more than one million people with HIV/AIDS in the United States , antiretroviral drugs such as efavirenz and other so-called non-nucleoside reverse transcriptase inhibitors in combination with other antiretrovirals can be a lifeline, because they slow the progress of viral infection, prolonging life.
New Understanding Of HIV Drug Resistance May Lead To Better Treatment
Investigators from the University of Pittsburgh's medical school say genetic mutations leading to drug-resistant HIV threaten the efficacy of non-nucleoside reverse transcriptase inhibitors.
Malnutrition decreases effectiveness of HIV treatment in pregnant African women
In Uganda the prescription of three antiretroviral drugs, which aim to suppress the virus to prevent disease progression, have resulted in huge reductions in HIV mortality rates.