Voltage dependence of beta-adrenergic...

Voltage dependence of beta-adrenergic modulation of conduction in the canine Purkinje fiber.

Although recent voltage-clamp and microelectrode studies have demonstrated beta-adrenergic modulation of Na+ current the modulation of conduction by catecholamines and the voltage dependence of that process have not been elucidated. To determine whether voltage-dependent modulation of conduction occurs in the presence of a beta-adrenergic agonist, the effect of 1 mumol/L isoproterenol on impulse propagation in canine Purkinje fibers was examined by using a dual-microelectrode technique.

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