Nov 3, 2009 | BMC Medicine
Adherence to isoniazid prophylaxis among HIV-infected children: a...
Tuberculosis contributes significantly to morbidity and mortality among HIV-infected children in sub-Saharan Africa.
Patient knows best: blinded assessment of nonadherence with...
While extreme nonadherence is readily apparent, it is rare compared to lesser degrees of nonadherence, which are difficult to predict.
TB treatment guidelines need to change, systematic reviews show
International guidelines for treating tuberculosis need to be updated to recommend six months of rifampicin treatment in first-line therapy for all countries, and to improve the ways in which relapsers and isoniazid-resistant patients are treated, according to two systematic reviews published this week in the open access journal PLoS Medicine .
Current Guidelines Need to Be Changed for Both First-line Treatment...
Every year nearly ten million people develop tuberculosis , a contagious infection, usually of the lungs.
Laboratory Sciences: Experimental Ocular Tuberculosis in Guinea Pigs
Objective To develop an animal model of intraocular tuberculosis with features of pulmonary TB and extrapulmonary dissemination to the eye.
Analysis of TB treatment studies identifies gaps in guidelines
International guidelines for treating tuberculosis are due for specific improvements, according to two research papers published this week in the open access journal PLoS Medicine .
Special Feature: Picture of the Month--Diagnosis
Picture of the Month - Diagnosis Arch Pediatr Adolesc Med. 2009;163 :864. Denouement and Discussion: Chronic Cutaneous Ulcer Cranial and vertebral magnetic resonance imaging revealed destruction of the second thoracic vertebra and a major paravertebral abscess, causing cord compression, which suggests tuberculous spondylitis.
Molecular detection of rifampin and isoniazid resistance to guide...
Drug-resistant tuberculosis is considered a real threat to the achievement of TB control.
Lilly and Other Organizations Fight Multidrug-Resistant Tuberculosis Around the World
Tuberculosis is one of the world's oldest diseases. It is curable, but in some parts of the world, you would never know it.
Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.
NEW Abstract Isoniazid is an essential drug used to treat tuberculosis. The mycobactericidal agents are INH adducts [INH-NAD ] of the pyridine nucleotide coenzymes, which are generated in vivo after INH activation and which bind to, and inhibit, essential enzymes.
Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.
NEW Abstract Isoniazid is an essential drug used to treat tuberculosis. The mycobactericidal agents are INH adducts [INH-NAD ] of the pyridine nucleotide coenzymes, which are generated in vivo after INH activation and which bind to, and inhibit, essential enzymes.
SAa s war on TB makes progress
South Africa is surging ahead in the fight against TB but drug-resistant strains still pose a huge threat, according to new research at the International Aids Society conference in Cape Town this week.
MDR-TB is particularly dangerous because it can give rise to extensively drug-resistant M. tuberculosis , which requires aggressive treatment using a combination of five different drugs.
Centers for Disease Control and Preve...
Relapse Associated with Active Disease Caused by Beijing Strain of Mycobacterium tuberculosis
Relapse Associated with Active Disease Caused by Beijing Strain of Mycobacterium tuberculosis 1 William J. Burman, Erin E. Bliven, Lauren Cowan, Lorna Bozeman, Payam Nahid, Lois Diem, and Andrew Vernon, for the Tuberculosis Trials Consortium Author affiliations: Denver Public Health, Denver Colorado, USA ; University of Colorado at Denver Health ...
Lancet Infectious Diseases Examines Spread Of XDR-TB
The journal Lancet Infectious Diseases examines the worldwide spread of extensively drug-resistant tuberculosis .
Targeting Tuberculosis on ADVANCE for Medical Laboratory Professionals
This "revolutionary" test will shorten the 2 to 4 months it now takes to detect multidrug-resistant TB down to mere hours, according to Mario Raviglione, MD, director, WHO tuberculosis program.
Promising Interim Results of a Study of TMC207, a New Experimental...
Promising Interim Results of a Study of TMC207, a New Experimental Drug for Treatment of Multidrug-resistant Tuberculosis By Ronald Baker, PhD Tuberculosis bacillus The June 4, 2009 issue of the New England Journal of Medicine features an article on the new experimental drug TMC207 for the treatment of multi-drug resistant tuberculosis .
Health Buzz: New Drug for Resistant Tuberculosis and Other Health News
The first new tuberculosis drug in 40 years has been shown to make current treatment 5 times more effective against drug-resistant TB, Reuters reported Wednesday.
New England Journal of Medicine
A Woman with AIDS and Tuberculosis with Progressive Cough, Dyspnea, and Wasting
Case 18-2009 - A 24-Year-Old Woman with AIDS and Tuberculosis with Progressive Cough, Dyspnea, and Wasting Douglas Wilson, M.B., Ch.B., Roco M. Hurtado, M.D., and Subba Digumarthy, M.D. Presentation of Case Dr.
Direct susceptibility testing for multi drug resistant tuberculosis: A meta-analysis
One of the challenges facing the tuberculosis control programmes in resource-limited settings is lack of rapid techniques for detection of drug resistant TB, particularly multi drug resistant tuberculosis .
Also on Topix