Aredia, Pamidronate News

Recovery of proximal tibia bone mineral density and strength, but not cancellous bone architecture, after long-term bisphosphonate or selective estrogen receptor modulator therapy in aged rats.

Traditionally OI was classified into OI types I to IV and thought to be only due to a defect in the collagen gene, however through the discovery of the new types of OIa 'V to VII, breakthroughs have been made in understanding the pathophysiology of autosomal recessive OI and new genetic mutations, such as in CRTAP and P3H1 genes.

Bones are formed, molded and absorbed continuously. Bone cells, called osteoblasts, are responsible for the new bone formation and cells known as osteoclasts absorb the bone.

Bisphosphonates are a class of drug that slow bone resorption by reducing osteoclast function.

Sun Pharmaceutical Industries Ltd. announced that together with its subsidiaries, it has received final approval from USFDA for several Abbreviated New Drug Applications .

It's not uncommon for arthritis patients to be prescribed one of the bisphosphonates.

Drug major Sun Pharmaceutical Industries today said the company, along with its subsidiary, has received abbreviated new drug application approval for four generic products from the US health regulator.

Sun Pharmaceutical Industries Ltd. announced that together with its subsidiaries, it has received final approval from USFDA for several Abbreviated New Drug Applications .