Cytoplasmic TDP-43 aggregation is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Here we investigated the role of exosomes in the secretion and propagation of TDP-43 aggregates.
A handful of dedicated runners wound their way through downtown Kenosha Friday night, some nine hours into a 35-hour journey from Milwaukee to Chicago. "We're getting to the point where thing start to get real - we're about a third of the way done," said organizer and runner Scott Kummer during a brief rest stop in what he bills "the world's longest Turkey Trot."
While some may groan at high drug prices or grumble at the growing collection of pills we need to keep healthy, it is indisputable some people wouldn't even be alive without the research and products of the pharmaceutical industry. "The students and their family presumably benefit from the pharmaceutical industry at some point in their lives," said Stephen Walsh, assistant to Mark Trudeau, president and CEO of Mallinckrodt Pharmaceuticals.
One of the most devastating symptoms of amyotrophic lateral sclerosis is its ability to slowly destroy people's ability to communicate even though their minds stay sharp and intact. A recent case study is raising hope for efforts to restore these abilities: a device implanted into the brain of an ALS patient has now given her limited communication skills in a home setting.
MediciNova, Inc., a biopharmaceutical company traded on the NASDAQ Global Market and the JASDAQ Market of the Tokyo Stock Exchange , today announced that the European Medicines Agency's Committee for Orphan Medicinal Products has issued a positive opinion recommending orphan medicinal product designation for MN-166 for the treatment of amyotrophic lateral sclerosis . Orphan-drug designation offers potential benefits including protocol assistance, fee waivers, and 10-year market exclusivity once the medicine is on the market in Europe.
An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/Wikipedia Amyotrophic lateral sclerosis , also known as Lou Gehrig's disease, is a progressive, fatal neurological disease that attacks the nerve cells controlling voluntary muscles.
Amyotrophic lateral sclerosis , also known as Lou Gehrig's disease, is a progressive, fatal neurological disease that attacks the nerve cells controlling voluntary muscles. No effective treatments have been found.